{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T15:59:12Z","timestamp":1770739152369,"version":"3.49.0"},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2007,1,19]],"date-time":"2007-01-19T00:00:00Z","timestamp":1169164800000},"content-version":"vor","delay-in-days":5497,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Industrial Med"],"published-print":{"date-parts":[[1992,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Machining fluids are widely used in a variety of common industrial metalworking operations to lubricate and cool both the tool and the working surfaces. Previous studies have suggested elevated respiratory, digestive, and skin cancers in exposed populations. This cohort study was initiated to assess whether long\u2010term exposure to machining fluids in the course of machining, grinding, and other cutting operations is associated with excess cancer mortality. The cohort includes more than 45,000 automobile production workers from 3 plants, almost 1 million years of follow\u2010up, over 10,000 deaths, and an extensive exposure assessment component. Standardized mortality ratios (SMRs) have been estimated for each of the 3 plants, using both U.S. as well as local populations as reference. Relative risks of 1.2\u20133. 1 have been observed for several specific respiratory and digestive cancers of a priori interest, including cancer of the stomach, large intestine, pancreas, lung, and larynx. In addition, elevated risks for leukemia and asthma were noted. Future exposure\u2010response analyses will provide the opportunity to identify relatively modest excesses in cause\u2010specific mortality risk associated with exposure to specific types (straight, soluble, or synthetic), additives, or components of machining fluids.<\/jats:p>","DOI":"10.1002\/ajim.4700220604","type":"journal-article","created":{"date-parts":[[2007,4,19]],"date-time":"2007-04-19T23:18:43Z","timestamp":1177024723000},"page":"809-824","source":"Crossref","is-referenced-by-count":68,"title":["Mortality studies of machining fluid exposure in the automobile industry I: A standardized mortality ratio analysis"],"prefix":"10.1002","volume":"22","author":[{"given":"Ellen A.","family":"Eisen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paige E.","family":"Tolbert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard R.","family":"Monson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas J.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,1,19]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajim.4700200404"},{"key":"e_1_2_1_3_1","first-page":"135","article-title":"Paraffin epithelioma of the scrotum","volume":"22","author":"Bell J","year":"1876","journal-title":"Edinburgh Med J"},{"key":"e_1_2_1_4_1","first-page":"1","article-title":"Skin cancer in the engineering industry from the use of mineral oil","volume":"7","author":"Cruickshank CND","year":"1950","journal-title":"Br J Ind Med"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1976.tb23098.x"},{"key":"e_1_2_1_6_1","first-page":"1025","article-title":"Further analysis of cancer mortality patterns among workers exposed to cutting oil mists","volume":"61","author":"Decoufl\u00e9 P","year":"1978","journal-title":"J Natl Cancer Inst"},{"key":"e_1_2_1_7_1","first-page":"225","article-title":"Low mortality rates in industrial cohort studies due to selection for work and survival in the industry","volume":"30","author":"Fox AJ","year":"1976","journal-title":"Br J Prev Soc Med"},{"key":"e_1_2_1_8_1","first-page":"1191","article-title":"Cancer mortality in metal workers","volume":"129","author":"Gallagher R","year":"1983","journal-title":"Can Med Assoc J"},{"key":"e_1_2_1_9_1","first-page":"51","article-title":"Occupational asthma due to an emulsified oil mist","volume":"42","author":"Hendy MS","year":"1985","journal-title":"Br J Ind Med"},{"key":"e_1_2_1_10_1","first-page":"333","article-title":"Cancer morbidity among men exposed to oil mist in the metal industry","volume":"23","author":"Jarvholm B","year":"1981","journal-title":"J Occup Med"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/00039896.1987.9934360"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajim.4700150603"},{"key":"e_1_2_1_13_1","first-page":"655","article-title":"A method for verifying the completeness of cohorts used in occupational mortality studies","volume":"21","author":"Marsh GM","year":"1979","journal-title":"J Occup Med"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000234816"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0010-4809(74)90010-X"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/00043764-198606000-00009"},{"key":"e_1_2_1_17_1","unstructured":"NIOSH: National Occupational Health Survey(1977): Volume III. 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