{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T22:31:31Z","timestamp":1785709891779,"version":"3.56.0"},"reference-count":15,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2007,1,19]],"date-time":"2007-01-19T00:00:00Z","timestamp":1169164800000},"content-version":"vor","delay-in-days":5497,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Industrial Med"],"published-print":{"date-parts":[[1992,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We investigated the cardiotoxic effects of 1.1,2\u2010Trichloro\u20101,2,2\u2010Trifluoroethane (fluorocarbon 113 or FC113) exposures among healthy workers cleaning rocket and ground support equipment for the National Aeronautic and Space Administration (NASA) programs. Exposure and ambulatory electrocardiographic (ECG) monitoring data were evaluated on 16 workers, each of whom was examined on exposed and nonexposed workdays. We examined whether there was a greater rate of dysrhythmias on an exposed workday relative to a nonexposed workday. Overall, we found no within subject differences in the rate of ventricular and supraventricular premature beats (number per 1.000 heart beats), fluctuations in the length of the P\u2010R interval, or heart rate. We found that levels of FC113 exposures below the Occupational Safety and Health Administration (OSHA) 8\u2010hour time\u2010weighted\u2010average (TWA) standard of 1,000 ppm did not induce cardiac dysrhythmias or subtle changes in cardiac activity. However, because fluorocarbons may sensitize the heart to epinephrine, this study's negative findings based on sedentary and fairly healthy workers may not be generalizable to other populations of workers who are not as healthy or engaged in more physically demanding work.<\/jats:p>","DOI":"10.1002\/ajim.4700220607","type":"journal-article","created":{"date-parts":[[2007,4,19]],"date-time":"2007-04-19T23:48:17Z","timestamp":1177026497000},"page":"851-857","source":"Crossref","is-referenced-by-count":10,"title":["Fluorocarbon 113 exposure and cardiac dysrhythmias among aerospace workers"],"prefix":"10.1002","volume":"22","author":[{"given":"Grace M.","family":"Egeland","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas F.","family":"Bloom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa M.","family":"Schnorr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard W.","family":"Hornung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony J.","family":"Suruda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen K.","family":"Wille","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,1,19]]},"reference":[{"key":"e_1_2_1_2_1","volume-title":"Documentation of Threshold Limit Values","author":"American Conference of Governmental Industrial Hygienists","year":"1980"},{"key":"e_1_2_1_3_1","first-page":"138","article-title":"Cardiac arrhythmias during occupational exposure to fluorinated hydrocarbons","volume":"47","author":"Antti\u2010Poika M","year":"1990","journal-title":"Br J Ind Med"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0300-483X(74)90040-7"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/0002889728506632"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1970.03170250031004"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1552-4604.1975.tb01437.x"},{"key":"e_1_2_1_8_1","first-page":"207","article-title":"Cardiac arrhythmia in refrigerator repairmen exposed to fluorocarbons","volume":"47","author":"Edling C","year":"1990","journal-title":"Br J Ind Med"},{"key":"e_1_2_1_9_1","unstructured":"Federal Register(1990): 1 1 2 \u2010Trichloro\u20101 2 2 \u2010trifluoroethane Vol 55:12819 April 6."},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/00039896.1984.10545862"},{"key":"e_1_2_1_11_1","volume-title":"NIOSH Manual of Analytical Methods","author":"National Institute for Occupational Safety and Health","year":"1990"},{"key":"e_1_2_1_12_1","volume-title":"Preventing death from excessive exposure to chlorofluorocarbon 113","author":"NIOSH Alert","year":"1989"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/00039896.1971.10665840"},{"key":"e_1_2_1_14_1","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1289\/ehp.7826275","article-title":"Physiological response to aerosol propellants","volume":"26","author":"Stewart RD","year":"1978","journal-title":"Environ Health Perspect"},{"key":"e_1_2_1_15_1","first-page":"130","article-title":"Effects of fluorocarbon propellants on respiratory flow and ECG","volume":"34","author":"Valic F","year":"1977","journal-title":"Br J Ind Med"},{"key":"e_1_2_1_16_1","first-page":"281","volume-title":"Cardiovascular Toxicology","author":"Zachari S","year":"1982"}],"container-title":["American Journal of Industrial Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajim.4700220607","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajim.4700220607","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T16:26:47Z","timestamp":1698078407000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajim.4700220607"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,1]]},"references-count":15,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1992,1]]}},"alternative-id":["10.1002\/ajim.4700220607"],"URL":"https:\/\/doi.org\/10.1002\/ajim.4700220607","archive":["Portico"],"relation":{},"ISSN":["0271-3586","1097-0274"],"issn-type":[{"value":"0271-3586","type":"print"},{"value":"1097-0274","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,1]]}}}