{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T02:28:10Z","timestamp":1774664890208,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2007,1,19]],"date-time":"2007-01-19T00:00:00Z","timestamp":1169164800000},"content-version":"vor","delay-in-days":4980,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Industrial Med"],"published-print":{"date-parts":[[1993,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The U.S. multiplant cohort mortality study of workers producing manufactured mineral fibers is finding increasing mortality from nephritis and\/or nephrosis. We examine other data sets to see if similar effects can be identified.<\/jats:p><jats:p>In a case\u2010referent study among Michigan patients with end\u2010stage renal disease (ESRD), men with exposures to silica have elevated odds ratio for ESRD.<\/jats:p><jats:p>In a California occupational mortality study based on 1979\u201381 data, a number of the construction trades, farmers, and farm laborers show excess mortality for renal disease. The highest mortality ratio is found in the category including insulation workers. This ratio remains significantly elevated when adjusted for estimated exposures to smoking, alcohol, and for socio\u2010economic status. California mortality data from 20 years earlier (1959\u201361) fail to show much excess renal disease in construction workers, but do for farmers. In Singapore, granite workers with a long\u2010term exposure to silica have excess excretion of albumin and similar compounds compared to less exposed controls, leading to the presumption that silica exposure can lead to silica nephrotoxicity.<\/jats:p><jats:p>Balkan nephropathy has been associated with consumption of well water high in silica. In the Negev of Israel, dust storms are a vehicle for increasing respiratory uptake of silica. The Beduin, thought to be a population with maximal exposures, have higher rates of ESRD than do Jews in the age groups over 60 years.<\/jats:p><jats:p>Although high blood concentrations of silica are found in persons with renal failure, the close association with elevated creatinine has been interpreted as evidence that the buildup of silica is due to renal failure, rather than vice\u2010versa.<\/jats:p><jats:p>The evidence is consistent with, but not yet compelling, that exposure to silica, which can be readily absorbed (or dissolved) from the lung, may increase the long\u2010term risk of renal disease including renal failure. \u00a9 1993 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajim.4700230605","type":"journal-article","created":{"date-parts":[[2007,4,20]],"date-time":"2007-04-20T10:16:25Z","timestamp":1177064185000},"page":"873-881","source":"Crossref","is-referenced-by-count":21,"title":["Fiberglass or silica exposure and increased nephritis or ESRD (end\u2010stage renal disease)"],"prefix":"10.1002","volume":"23","author":[{"given":"John R.","family":"Goldsmith","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David F.","family":"Goldsmith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,1,19]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"121","article-title":"Simple siliceous pneumoconiosis in Negev Beduin. 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(1987): \u201cCalifornia Occupational Mortality 1979\u20131981.\u201d Sacramento: California State Department of Health Services 181 ppplus tables."},{"key":"e_1_2_1_16_1","first-page":"311","volume-title":"Silica, Silicosis and Cancer: Controversy in Occupational Medicine","author":"Kurppa K","year":"1986"},{"key":"e_1_2_1_17_1","first-page":"401","article-title":"R\u00f2le etiopathog\u00e9nique des silicates erosifs dans la nephrite end\u00e9mique (French)","volume":"73","author":"Markovic B","year":"1965","journal-title":"Presse Med"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/00043764-199007000-00009"},{"key":"e_1_2_1_19_1","first-page":"228","article-title":"Increase in blood silicon in patients with renal failure","volume":"33","author":"Mauras Y","year":"1980","journal-title":"Biomedicine"},{"key":"e_1_2_1_20_1","first-page":"35","article-title":"A study of silica nephrotoxicity in exposed silicotic and non\u2010silicotic workers","volume":"49","author":"Ng TP","year":"1992","journal-title":"Br J Ind Med"},{"key":"e_1_2_1_21_1","first-page":"80","volume-title":"Occupational Mortality in the State of California, 1959\u201361","author":"Petersen GR","year":"1980"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1159\/000186215"},{"key":"e_1_2_1_23_1","doi-asserted-by":"crossref","unstructured":"J Work Env Hlth 1986 12 Suppl 1 Contributions to the IARC study of mortality and cancer incidence among man\u2010made mineral fiber production workers Scand","DOI":"10.5271\/sjweh.2177"},{"key":"e_1_2_1_24_1","first-page":"5","article-title":"Ten years of epidemiologic investigations on man\u2010made mineral fibers and health","volume":"1","author":"Saracci R","year":"1986","journal-title":"Scand J Work Env Hlth 12; Suppl."},{"key":"e_1_2_1_25_1","first-page":"675","article-title":"Rapidly progressive crescentic glomerulonephritis in a sandblaster with silicosis","volume":"46","author":"Sherson D","year":"1989","journal-title":"Br J Ind Med"},{"key":"e_1_2_1_26_1","first-page":"34","article-title":"The man\u2010made mineral fiber European historical cohort Study: Extension of the follow\u2010up","volume":"12","author":"Simonato L","year":"1986","journal-title":"Scand J Work Env Hlth"},{"key":"e_1_2_1_27_1","unstructured":"SingletonJA BeaumontJJ. (1989):COMSII. Suppl 1:34\u201347. California Occupational Mortality 1979\u20131981 adjusted for smoking alcohol and socioeconomic status. Prepared for the Health Demographics Section Health Data and Statistics Branch California Department of Health Services Sacramento December 21."},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.80.2.153"}],"container-title":["American Journal of Industrial Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajim.4700230605","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajim.4700230605","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T19:48:55Z","timestamp":1698176935000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajim.4700230605"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,6]]},"references-count":27,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1993,6]]}},"alternative-id":["10.1002\/ajim.4700230605"],"URL":"https:\/\/doi.org\/10.1002\/ajim.4700230605","archive":["Portico"],"relation":{},"ISSN":["0271-3586","1097-0274"],"issn-type":[{"value":"0271-3586","type":"print"},{"value":"1097-0274","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,6]]}}}