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A new systematic approach to evaluating available data for evidence of disease\u2010causing agents in organic dust is proposed. It combines, in a matrix fashion, principles of Koch's postulates, River's postulates, principles of epidemiologic determinants, and weight of evidence theory. By applying these principles in a systematic fashion, the strength of the scientific evidence for a specific agent can objectively be evaluated. \u00a9 1994 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajim.4700250109","type":"journal-article","created":{"date-parts":[[2007,4,20]],"date-time":"2007-04-20T16:56:20Z","timestamp":1177088180000},"page":"33-39","source":"Crossref","is-referenced-by-count":11,"title":["Agents in organic dust: Criteria for a causal relationship"],"prefix":"10.1002","volume":"25","author":[{"given":"Kelley J.","family":"Donham","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter S.","family":"Thorne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,1,19]]},"reference":[{"key":"e_1_2_1_2_1","volume-title":"The Battle Against Bacteria","author":"Baldry PE","year":"1965"},{"key":"e_1_2_1_3_1","volume-title":"The Discoverers","author":"Boorstin DJ","year":"1983"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajim.4700100305"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajim.4700100310"},{"key":"e_1_2_1_6_1","volume-title":"A History of Medical Bacteriology and Immunology","author":"Foster WD","year":"1970"},{"key":"e_1_2_1_7_1","volume-title":"Galen on the Natural Faculties","author":"Galen","year":"1979"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/003591576505800503"},{"key":"e_1_2_1_9_1","first-page":"260","volume-title":"Hippocratic Writings","author":"Hippocrates","year":"1978"},{"key":"e_1_2_1_10_1","first-page":"185","volume-title":"Epidemiology: An Introductory Text","author":"Mausner JS","year":"1985"},{"key":"e_1_2_1_11_1","first-page":"73","volume-title":"The Fundamental Ideas of Medicine: A Brief History of Medicine","author":"McManus JFA","year":"1963"},{"key":"e_1_2_1_12_1","first-page":"73","volume-title":"Risk Assessment in the Federal Government: Managing the Process","author":"National Research Council","year":"1983"},{"key":"e_1_2_1_13_1","first-page":"70","volume-title":"Fiscal Year 1991 Annual Plan","author":"National Toxicology Program","year":"1991"},{"key":"e_1_2_1_14_1","first-page":"10372","article-title":"Chemical Carcinogens: A Review of the Science and its Associated Principles","volume":"50","author":"Office of Science and Technology Policy","year":"1985","journal-title":"Fed Reg"},{"key":"e_1_2_1_15_1","volume-title":"An Almanac For Moderns","author":"Peattie DC","year":"1935"},{"key":"e_1_2_1_16_1","volume-title":"Microbes and Man","author":"Reid RW","year":"1975"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajim.4700170146"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajim.4700170102"},{"key":"e_1_2_1_19_1","first-page":"193","article-title":"Health effects of organic dusts in the farm environment. 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