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In addition, she was found to have markedly elevated bone lead levels, as measured by K\u2010x\u2010ray fluorescence (154 \/pm 5 in the mid\u2010tibia and 253 \/pm 6 \u03bc\/g bone mineral in the patella), and an increased serum osteocalcin level (2.76 nmol\/1), reflecting the increased bone turnover that often accompanies hyperthyroidism. During treatment with propylthiouracil, serial observations demonstrated a decline in serum osteocalcin that paralleled a decline in blood lead levels. Bone lead levels did not change appreciably. The patient also continued to have lingering neuropsychological symptoms consistent with chronic lead effects. We suggest that increased bone turnover accompanying thyrotoxicosis led to clinically significant lead poisoning in this patient, due to mobilization of accumulated bone lead stores acquired many years earlier. This phenomenon raises the general issue of more subtle forms of lead exposure from increased bone turnover states (e.g., osteoporosis). \u00a9 1994 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajim.4700250309","type":"journal-article","created":{"date-parts":[[2007,4,20]],"date-time":"2007-04-20T20:16:57Z","timestamp":1177100217000},"page":"417-424","source":"Crossref","is-referenced-by-count":59,"title":["Lead poisoning from mobilization of bone stores during thyrotoxicosis"],"prefix":"10.1002","volume":"25","author":[{"given":"Rose H.","family":"Goldman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"White","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen N.","family":"Kales","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,1,19]]},"reference":[{"key":"e_1_2_1_2_1","unstructured":"ATSDR(July1988): \u201cThe Nature and Extent of Lead Poisoning in Children in the United States: A Report to Congress.\u201d Atlanta Agency for Toxic Substances and Disease Registry. 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