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The extent of symptoms was evaluated using a specific organic dust questionnaire. Bronchial reactivity was assessed with the methacholine challenge test. An increased incidence of organic dust toxic syndrome (ODTS), mucous membrane irritation (MMI), and chronic bronchitis (CB) was found among farmers working with swine or other animals. Pulmonary function baseline values were normal. Bronchial reactivity was increased and related to subjective symptoms of MMI and CB. 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