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Yet there remains a gap in our understanding of trends in opioid\u2010related harms over time among injured workers. We estimated trends in hospital encounters for opioid\u2010related harms among injured workers in Ontario, Canada from 2006 to 2022.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study used linked workers' compensation (1983\u20132019) and hospitalization and emergency department (ED) (2006\u20132022) data from 1.7 million injured workers. Rates of opioid\u2010related poisonings and mental and behavioral disorders were estimated for all workers, as well as by age, sex, and occupational group. Joinpoint regression was used to analyze trends and estimate average annual percent change (AAPC) in rates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Rates of harms significantly increased across all age groups and sexes, with the highest increases among male workers and those aged 35\u201344. There was also variation by occupation. For poisonings, some of the largest increases in ED visits and hospitalizations were among workers in machining (ED visits\u2009=\u2009AAPC 18.5%, 95% CI 0.0%\u201340.5%; hospitalizations\u2009=\u2009AAPC 8.1%, 95% CI 3.4%\u201313.0%), and in construction trades (ED visits\u2009=\u2009AAPC 15.0%, 95% CI 10.4%\u201319.7%; hospitalizations\u2009=\u2009AAPC 6.5%, 95% CI 4.2%\u20138.8%). For mental and behavioral disorders, ED visits and hospitalizations were highest among workers in clerical work (ED visits\u2009=\u2009AAPC 12.4%, 95% CI 0.1%\u201326.2%; hospitalizations\u2009=\u2009AAPC 12.1%, 95% CI 7.9%\u201316.5%) and in materials handling (ED visits\u2009=\u2009AAPC 11.6%, 95% CI 1.8%\u201322.3%, hospitalizations\u2009=\u2009AAPC 14.2%, 95% CI 8.4%\u201320.3%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Rates of opioid\u2010related harms significantly increased over time among injured workers in Ontario, with substantial increases within certain occupational groups. Findings suggest injured workers should be a priority in ongoing surveillance and policy responses.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ajim.70136","type":"journal-article","created":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T05:03:19Z","timestamp":1789448599000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Trends in Opioid\u2010Related Poisonings and Mental and Behavioral Disorders From 2006 to 2022 Among a Large Cohort of Injured Workers in Ontario, Canada"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8228-1632","authenticated-orcid":false,"given":"Jeavana","family":"Sritharan","sequence":"first","affiliation":[{"name":"Occupational Cancer Research Centre, Ontario Health Toronto Ontario Canada"},{"name":"Dalla Lana School of Public Health University of Toronto Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-6450-8610","authenticated-orcid":false,"given":"Chaojie","family":"Song","sequence":"additional","affiliation":[{"name":"Occupational Cancer Research Centre, Ontario Health Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul A.","family":"Demers","sequence":"additional","affiliation":[{"name":"Occupational Cancer Research Centre, Ontario Health Toronto Ontario Canada"},{"name":"Dalla Lana School of Public Health University of Toronto Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-4670-7660","authenticated-orcid":false,"given":"Fateme","family":"Kooshki","sequence":"additional","affiliation":[{"name":"Occupational Cancer Research Centre, Ontario Health Toronto Ontario Canada"},{"name":"Dalla Lana School of Public Health University of Toronto Toronto Ontario Canada"},{"name":"Institute for Work &amp; Health Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7892-5626","authenticated-orcid":false,"given":"Nancy","family":"Carnide","sequence":"additional","affiliation":[{"name":"Dalla Lana School of Public Health University of Toronto Toronto Ontario Canada"},{"name":"Institute for Work &amp; Health Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,14]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"Statistics Canada 2025 Fall and Drug Overdose Deaths Are Main Contributors as Accidental Deaths Continue to Increase 2017 to 2022 https:\/\/www150.statcan.gc.ca\/n1\/daily-quotidien\/250219\/dq250219b-eng.htm."},{"key":"e_1_2_11_3_1","unstructured":"National Center for Health Statistics (NCHS) Centers for Disease Control and Prevention Drug Overdose Deaths 2024 https:\/\/www.cdc.gov\/nchs\/hus\/topics\/drug-overdose-deaths.htm."},{"key":"e_1_2_11_4_1","unstructured":"Government of Canada Opioid\u2010 and Stimulant\u2010related Harms in Canada 2024 https:\/\/health-infobase.canada.ca\/substance-related-harms\/opioids-stimulants\/."},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2025.14997"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugpo.2025.105022"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lana.2023.100437"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugpo.2019.01.010"},{"key":"e_1_2_11_9_1","unstructured":"F.Ahmad J.Cisewski L.Rossen andP.Sutton 2024 Provisional Drug Overdose Death Counts. 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