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Genet."],"published-print":{"date-parts":[[2001,12,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Gene identification in common disorders such as Alzheimer disease and breast cancer has greatly profited from the use of age of onset as criterion to delineate subgroups of disease characterized by different inheritance patterns. In bipolar affective disorder, where the majority of linkage studies have produced conflicting results, studies reporting clinical characteristics and familial occurrence of disease have suggested that age of onset might serve as an indicator for identifying more homogeneous subgroups of disease. Our study was the first to examine this hypothesis by the means of segregation analysis. We investigated a sample of 177 bipolar I probands recruited from consecutive admissions and their first\u2010 and second\u2010degree relatives (2,407 subjects). Probands were subdivided into an early\u2010onset (n\u2009=\u2009107) and a late\u2010onset group (n\u2009=\u200970) using an age of onset of 25 as a cut\u2010off point. This age was chosen because the observed age of onset distribution was bimodal with a cut\u2010off of 25 years. Morbid risks for affective disorder were found significantly higher (<jats:italic>P<\/jats:italic>\u2009=\u20090.01) in relatives of probands with an early onset than in probands with late onset of disease. The segregation analysis showed that the disease is transmitted differently in early\u2010 and late\u2010onset groups. In the early\u2010onset group, a non\u2010Mendelian major gene with a polygenic component was favored while the data in the late\u2010onset group were compatible with a multifactorial model. This result may have important implications for future molecular studies aiming at the identification of disease\u2010associated genes. \u00a9 2001 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.10047","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T04:51:41Z","timestamp":1030251101000},"page":"765-773","source":"Crossref","is-referenced-by-count":78,"title":["Different familial transmission patterns in bipolar I disorder with onset before and after age 25"],"prefix":"10.1002","volume":"105","author":[{"given":"Maria","family":"Grigoroiu\u2010Serbanescu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Martinez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus M.","family":"N\u00f6then","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihaela","family":"Grinberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorina","family":"Sima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Propping","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elvira","family":"Marinescu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihaela","family":"Hrestic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2001,11,7]]},"reference":[{"key":"e_1_2_5_2_1","volume-title":"Diagnostic and statistical manual of mental disorders","author":"American Psychiatric Association","year":"1994"},{"issue":"1","key":"e_1_2_5_3_1","first-page":"S20","article-title":"Admixture analysis of age at onset in bipolar affective disorder","volume":"4","author":"Bellivier F","year":"1999","journal-title":"Mol Psychiatry"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.58.5.510"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0327(99)00083-X"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.med.51.1.465"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.157.2.213"},{"key":"e_1_2_5_8_1","first-page":"135","article-title":"The EM and the SEM algorithms for mixtures: statistical and numerical aspects","volume":"32","author":"Celeux G","year":"1990","journal-title":"Cahiers CERO"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.142.7.817"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000152448"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0327(85)90068-0"},{"key":"e_1_2_5_12_1","volume-title":"Structured clinical interview for DSM\u2010IV axis II personality disorders (SCID\u2010II version 2.0)","author":"First M","year":"1994"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01065722"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19960409)67:2<202::AID-AJMG11>3.0.CO;2-N"},{"key":"e_1_2_5_15_1","first-page":"274","article-title":"Segregation and linkage analyses in families of patients with bipolar, unipolar and schizoaffective mood disorders","volume":"35","author":"Goldin LR","year":"1983","journal-title":"Am J Hum Genet"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1995.tb09598.x"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.170.2.162"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19980907)81:5<397::AID-AJMG8>3.0.CO;2-Q"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19961122)67:6<546::AID-AJMG6>3.0.CO;2-F"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0327(99)00151-2"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1159\/000153231"},{"key":"e_1_2_5_22_1","unstructured":"LalouelJM YeeS.1980.POINTER: a computer program for complex segregation analysis with pointers\u2014technical report. 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