{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T10:24:33Z","timestamp":1761560673804},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2001,12,13]],"date-time":"2001-12-13T00:00:00Z","timestamp":1008201600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Med. Genet."],"published-print":{"date-parts":[[2002,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Transcervical embryoscopy, a new technique for direct visualization of the first trimester conceptus was carried out in 116 cases of missed abortion. Embryonic neural tube defects and other localized developmental defects, were diagnosed in 10 out of 99 cases in which a complete embryoscopic evaluation was possible. All eight successfully karyotyped cases had a numerical chromosomal abnormality. A ninth unkaryotyped embryo with open spina bifida showed, on embryoscopy, a malformation pattern highly suggestive of triploidy. Our embryoscopic and cytogenetic findings provide valuable information for genetic counseling in future pregnancies. \u00a9 2001 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.10114","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T16:35:44Z","timestamp":1030293344000},"page":"52-57","source":"Crossref","is-referenced-by-count":14,"title":["Neural tube defects in missed abortions: embryoscopic and cytogenetic findings"],"prefix":"10.1002","volume":"107","author":[{"given":"Tom","family":"Philipp","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dagmar K.","family":"Kalousek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,12,13]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.1978.tb04136.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.316.7146.1712"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320250219"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1997.10060410.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.13.1.9"},{"key":"e_1_2_6_7_1","first-page":"153","article-title":"Anatomical and chromosomal abnormalities in specimens of early spontaneous abortions: seven years experience","volume":"23","author":"Kalousek DK","year":"1987","journal-title":"Birth Defects"},{"key":"e_1_2_6_8_1","first-page":"53","article-title":"Early spontaneous abortion: morphologic and karyotypic findings in 3912 cases","volume":"29","author":"Kalousek DK","year":"1993","journal-title":"Birth Defects Orig Artic Ser"},{"key":"e_1_2_6_9_1","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1093\/oxfordjournals.humrep.a138078","article-title":"Mifepristone (RU486) induces embryo expulsion in first trimester non\u2010developing pregnancies: a prospective randomized trial","volume":"8","author":"Lelaider C","year":"1993","journal-title":"Hum Reprod"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1086\/302878"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320320317"},{"key":"e_1_2_6_12_1","first-page":"974","volume-title":"The developing human. 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