{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T17:53:53Z","timestamp":1790186033659,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2001,11,29]],"date-time":"2001-11-29T00:00:00Z","timestamp":1006992000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Med. Genet."],"published-print":{"date-parts":[[2002,1,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Chromosome 16p13 has been shown to display modest linkage signals for mood disorders in a number of studies. An interesting candidate gene in this region is the adenylate cyclase (AC) type 9 gene (<jats:italic>ADCY9<\/jats:italic>). ACs are critical in neuronal signaling, and perturbation of brain AC activity has been reported in mood disorder postmortem brains. ACs may also act as targets of antidepressants. Two distinct length transcripts for the <jats:italic>ADCY9<\/jats:italic> gene have been reported, but molecular mechanisms are unknown. To investigate the potential role of <jats:italic>ADCY9<\/jats:italic> in mood disorders, we clarified alternative poly(A) sites for the two mRNA species, delineated the exon\u2010intron structure, and screened the gene for genetic variants. The two transcripts encoded by <jats:italic>ADCY9<\/jats:italic> shared the first 10 exons, but exon 11 was shorter in one of the mRNA species. Seven single nucleotide polymorphisms, including a missense mutation and one polymorphic microsatellite repeat in the 3\u2032\u2010UTR, were identified. However, a case\u2010control study using the missense polymorphism, 2316A\u2009&gt;\u2009G (Ile772Met), and the tetranucleotide repeat (TTTA)n showed no significant association with mood disorders in Japanese samples. The DNA polymorphisms detected in this study can be tested in other ethnic samples and\/or other psychiatric diseases. \u00a9 2002 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.10117","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T22:20:15Z","timestamp":1030314015000},"page":"84-92","source":"Crossref","is-referenced-by-count":25,"title":["Molecular analysis, mutation screening, and association study of adenylate cyclase type 9 gene (<i>ADCY9<\/i>) in mood disorders"],"prefix":"10.1002","volume":"114","author":[{"given":"Tomoko","family":"Toyota","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eiji","family":"Hattori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne","family":"Meerabux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuo","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Saito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruo","family":"Shibuya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Nankai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeo","family":"Yoshikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2001,11,29]]},"reference":[{"key":"e_1_2_7_2_1","volume-title":"Diagnostic 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