{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T22:41:51Z","timestamp":1790462511942,"version":"4.1.0"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2001,12,5]],"date-time":"2001-12-05T00:00:00Z","timestamp":1007510400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Med. Genet."],"published-print":{"date-parts":[[2002,1,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Autistic disorder is a pervasive neurodevelopmental disorder characterized by deficits in language and social communication, as well as stereotyped patterns of behavior. Peak LOD scores from several genomic screening efforts indicate the presence of an autistic disorder susceptibility locus within the distal long arm of human chromosome 7 (7q31\u2010q35). Wassink et al. [\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"#bib21\">2001<\/jats:ext-link>\n                    : Am J Med Genet 105:406\u2013413] reported that\n                    <jats:italic>WNT2<\/jats:italic>\n                    , located at 7q31, influences genetic risk in autistic disorder. These findings were enhanced when examined in a subset of families with severe language impairment. WNT genes encode secreted growth factor\u2013like proteins that participate in growth regulation, differentiation, and tumorigenesis. We tested for genetic association of two\n                    <jats:italic>WNT2<\/jats:italic>\n                    variants in an independent data set of 135 singleton and 82 multiplex families. No significant association was found between autistic disorder and the\n                    <jats:italic>WNT2<\/jats:italic>\n                    genotypes in either the overall data set or in the language\u2010impaired subset of families. However, differences in allele frequencies of the 3\u2032 UTR single nucleotide polymorphism between the present population and that of Wassink et al. may account for the inability to detect association between\n                    <jats:italic>WNT2<\/jats:italic>\n                    and autistic disorder in the present data set. We also screened the two reported autistic disorder mutations previously detected by Wassink et al. We did not identify any activating mutation in the coding region of the\n                    <jats:italic>WNT2<\/jats:italic>\n                    gene. Thus, we conclude that activating mutations of the\n                    <jats:italic>WNT2<\/jats:italic>\n                    gene are not a major contributor to the development of autistic disorder in these data. \u00a9 2001 Wiley\u2010Liss, Inc.\n                  <\/jats:p>","DOI":"10.1002\/ajmg.10182","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T18:20:15Z","timestamp":1030299615000},"page":"106-109","source":"Crossref","is-referenced-by-count":97,"title":["No association between the\n                    <i>WNT2<\/i>\n                    gene and autistic disorder"],"prefix":"10.1002","volume":"114","author":[{"given":"Pinky A.","family":"McCoy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujun","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chantelle M.","family":"Wolpert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shannon L.","family":"Donnelly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison","family":"Ashley\u2010Koch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heidi L.","family":"Abel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah A.","family":"Ravan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth K.","family":"Abramson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harry H.","family":"Wright","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. Robert","family":"DeLong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael L.","family":"Cuccaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John R.","family":"Gilbert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret A.","family":"Pericak\u2010Vance","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2001,12,5]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1006\/geno.1999.5968"},{"key":"e_1_2_5_3_1","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1002\/(SICI)1096-8628(19991215)88:6<609::AID-AJMG7>3.0.CO;2-L","article-title":"An autosomal genomic screen for autism: collaborative linkage study of autism","volume":"88","author":"Barrett S","year":"1999","journal-title":"Am J Hum Genet"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0955-0674(98)80140-3"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1086\/302577"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19991215)88:6<609::AID-AJMG7>3.0.CO;2-L"},{"key":"e_1_2_5_7_1","first-page":"1665A","article-title":"Factor\u2010analysis of behavorial characteristics in Autistic disorder (AD)","volume":"67","author":"Cuccaro M","year":"2000","journal-title":"Am J Hum Genet"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0298-168"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1086\/303034"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291799008508"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/10.9.973"},{"key":"e_1_2_5_12_1","first-page":"357","article-title":"The SPCH1 region on human 7q31: genomic characterization of the critical interval and localization of translocations associated with speech and language disorder","volume":"67","author":"Lai CSL","year":"2000","journal-title":"Am J Med Genet"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02172145"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0074-7742(08)60569-3"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2272(200001)18:1<48::AID-GEPI4>3.0.CO;2-S"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/8.5.805"},{"key":"e_1_2_5_17_1","first-page":"717","article-title":"Latent\u2010class analysis of recurrence risks for complex phenotypes with selection and measurement error: a twin and family history study of autism","volume":"57","author":"Pickles A","year":"1995","journal-title":"Am J Hum Genet"},{"key":"e_1_2_5_18_1","first-page":"101","article-title":"Wnt factors in axonal remodeling and synaptogenesis","volume":"65","author":"Salinas PC","year":"1999","journal-title":"Biochem Soc Symp"},{"key":"e_1_2_5_19_1","first-page":"201","volume-title":"Approaches to gene mapping in complex human diseases","author":"Vance JM","year":"1998"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1086\/303005"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(20000403)96:2<228::AID-AJMG20>3.0.CO;2-G"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1401"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.cellbio.14.1.59"}],"container-title":["American Journal of Medical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajmg.10182","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajmg.10182","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,19]],"date-time":"2023-11-19T06:10:05Z","timestamp":1700374205000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajmg.10182"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,12,5]]},"references-count":22,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2002,1,8]]}},"alternative-id":["10.1002\/ajmg.10182"],"URL":"https:\/\/doi.org\/10.1002\/ajmg.10182","archive":["Portico"],"relation":{},"ISSN":["0148-7299","1096-8628"],"issn-type":[{"value":"0148-7299","type":"print"},{"value":"1096-8628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,12,5]]}}}