{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T01:45:28Z","timestamp":1791164728806,"version":"4.1.0"},"reference-count":218,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2002,3,18]],"date-time":"2002-03-18T00:00:00Z","timestamp":1016409600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Med. Genet."],"published-print":{"date-parts":[[2002,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Teratogenic causes of holoprosencephaly are critically assessed. A brief general review of holoprosencephaly is followed by four tables summarizing etiologic factors. Subjects evaluated here include: 1) maternal diabetes; 2) ethyl alcohol; 3) retinoic acid; 4) mutated genes and teratogens involving the sonic hedgehog signaling network and cholesterol biosynthesis; and 5) cholesterol trafficking, sterol adducts, target tissue response, and sterol sensing domain. \u00a9 2002 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.10258","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T23:15:07Z","timestamp":1030317307000},"page":"1-15","source":"Crossref","is-referenced-by-count":170,"title":["Teratogenesis of holoprosencephaly"],"prefix":"10.1002","volume":"109","author":[{"suffix":"Jr.","given":"M. Michael","family":"Cohen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kohei","family":"Shiota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2002,3,22]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/jez.1400670203"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jez.1400750203"},{"key":"e_1_2_12_4_1","first-page":"187","article-title":"Pathogenesis of retinoid\u2010induced hindbrain malformations in an experimental model","volume":"14","author":"Alles AJ","year":"1992","journal-title":"Clin Dysmorphol"},{"key":"e_1_2_12_5_1","first-page":"200","article-title":"Desmosterolosis presenting with multiple congenital anomalies and profound developmental delay","volume":"23","author":"Andersson HC","year":"2000","journal-title":"J Inherit Metab Dis"},{"key":"e_1_2_12_6_1","first-page":"326A","article-title":"Diabetic embryopathy: mechanism involves myo\u2010inositol and arachidonic acid","volume":"20","author":"Baker L","year":"1986","journal-title":"Pediatr Res"},{"key":"e_1_2_12_7_1","volume-title":"Antenatal pathology and hygiene","author":"Ballantyne JW","year":"1904"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-176-41842"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19990625)89:2<116::AID-AJMG10>3.0.CO;2-4"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(83)80185-1"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(72)90791-0"},{"key":"e_1_2_12_12_1","first-page":"191","article-title":"Multiple roles of cholesterol in hedgehog protein biogenesis and signaling","author":"Beachy PA","year":"1997","journal-title":"Cold Spring Harb Symp Quant Biol"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(80)80645-7"},{"key":"e_1_2_12_14_1","first-page":"324","article-title":"Recurrence of holoprosencephaly in families with a positive history","volume":"24","author":"Benke PJ","year":"1983","journal-title":"Clin Genet"},{"key":"e_1_2_12_15_1","first-page":"1164","article-title":"A congenital cyclopian\u2010type malformation in lambs induced by maternal ingestion of a range plant, Veratrum californicum","volume":"24","author":"Binns W","year":"1963","journal-title":"Am J Vet Res"},{"key":"e_1_2_12_16_1","first-page":"839","article-title":"Chronologic evaluation of teratogenicity in sheep fed Veratrum californicum","volume":"147","author":"Binns W","year":"1965","journal-title":"J Am Vet Med Assoc"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1998.8995"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320370328"},{"key":"e_1_2_12_19_1","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1007\/BF00340388","article-title":"\u00dcber fr\u00fchkindliche Hirnsch\u00e4digung bei der Cytomegalie und ihre Abgrenzung gegen\u00fcber der Toxoplasmose","volume":"193","author":"Born E","year":"1955","journal-title":"Arch Psychiat Nervenkr"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/10.8.791"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/2484"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420080104"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320280110"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.277.5323.228"},{"key":"e_1_2_12_25_1","first-page":"647","article-title":"Deux cas de cyclopie","volume":"23","author":"Castel Y","year":"1976","journal-title":"Ann P\u00e9diatr (Paris)"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9926(199712)56:6<350::AID-TERA2>3.0.CO;2-#"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0929-693X(97)86831-5"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1064437"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/383407a0"},{"key":"e_1_2_12_30_1","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1080\/15513819609169308","article-title":"Retinoic acid embryopathy: case report and review of literature","volume":"165","author":"Coberly S","year":"1996","journal-title":"Pediatr Pathol Lab Med"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420400304"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320340232"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4613-0785-3_4"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-0020.1999.283280314.x"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1546"},{"issue":"2","key":"e_1_2_12_36_1","first-page":"113","article-title":"Genetic considerations in a sibship of cyclopia and clefts","volume":"5","author":"Cohen MM","year":"1969","journal-title":"Birth Defects: Orig Artic Ser"},{"key":"e_1_2_12_37_1","first-page":"196","article-title":"Perspectives on holoprosencephaly. Part II. Central nervous system, craniofacial anatomy, syndrome commentary, diagnostic approach, and experimental studies","volume":"12","author":"Cohen MM","year":"1992","journal-title":"J Craniofac Genet Dev Biol"},{"issue":"7","key":"e_1_2_12_38_1","first-page":"125","article-title":"Holoprosencephaly and facial dysmorphia: nosology, etiology and pathogenesis","volume":"7","author":"Cohen MM","year":"1971","journal-title":"Birth Defects: Orig Artic Ser"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.280.5369.1603"},{"key":"e_1_2_12_40_1","first-page":"1","article-title":"Corr\u00e9lation et diff\u00e9rentiations: essai de morphologie causale sur la t\u00eate des amphibies","volume":"71","author":"Cotronei G","year":"1922","journal-title":"Arch Ital de Biol T"},{"key":"e_1_2_12_41_1","first-page":"473","article-title":"Suscettibilit\u00e0 differenziale gradiente assiale e rapporti tra correlazioni e differenziazione","volume":"31","author":"Cotronei G","year":"1922","journal-title":"Rend R Acad Lincei Cl Sci Fis Mat e Nat"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1993.00540070083022"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s100249900004"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19960823)64:3<465::AID-AJMG4>3.0.CO;2-O"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19970131)68:3<263::AID-AJMG4>3.0.CO;2-N"},{"key":"e_1_2_12_46_1","first-page":"171","article-title":"Monde de la formation de la cyclopie","volume":"106","author":"Dareste C","year":"1891","journal-title":"Ann Ocul"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.290.5500.2295"},{"key":"e_1_2_12_48_1","first-page":"165","article-title":"Altered cholesterol biosynthesis in rats: a model for Smith\u2010Lemli\u2010Opitz syndrome","volume":"51","author":"Dehart DB","year":"1995","journal-title":"Teratology"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-195910000-00014"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.8.3.193"},{"key":"e_1_2_12_51_1","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1096\/fasebj.10.9.8801166","article-title":"Ethanol inhibition of retinoic acid synthesis as a potential mechanism for fetal alcohol syndrome","volume":"109","author":"Deltour L","year":"1996","journal-title":"FASEB J"},{"key":"e_1_2_12_52_1","first-page":"431","volume-title":"Handbook of clinical neurology","author":"DeMyer WE","year":"1977"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.13.11.913"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.34.2.256"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1002020305"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198110013051415"},{"key":"e_1_2_12_57_1","doi-asserted-by":"crossref","first-page":"411","DOI":"10.2337\/diab.42.3.411","article-title":"Diabetes and embryonic malformations: role of substrate\u2010induced free\u2010oxygen radical production of dysmorphogenesis in cultured rat embryos","volume":"42","author":"Eriksson UJ","year":"1993","journal-title":"Diabetes"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-9525(97)01377-2"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/26013"},{"key":"e_1_2_12_60_1","first-page":"255","article-title":"Influence du repos sur les effets de l'exposition pr\u00e9lable aux vapeurs d'alcool avant l'incubation de l'oeuf de poule","author":"F\u00e9r\u00e9 C","year":"1899","journal-title":"C R Seances Soc Biol Fil"},{"key":"e_1_2_12_61_1","first-page":"796","article-title":"Note sur l'influence de l'\u00e9chauffement pr\u00e9lable sur l'incubation de l'oeuf de poule","author":"F\u00e9r\u00e9 C","year":"1900","journal-title":"C R Seances Soc Biol Fil"},{"key":"e_1_2_12_62_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19980113)75:2<145::AID-AJMG5>3.0.CO;2-S"},{"key":"e_1_2_12_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2275(20)43173-6"},{"key":"e_1_2_12_64_1","first-page":"293","article-title":"Cycloc\u00e9phalie: morphogenese et mecanisme de la production","volume":"47","author":"Giroud A","year":"1963","journal-title":"Arch Histol Embryol"},{"key":"e_1_2_12_65_1","doi-asserted-by":"publisher","DOI":"10.1038\/34848"},{"key":"e_1_2_12_66_1","doi-asserted-by":"publisher","DOI":"10.5962\/bhl.title.50400"},{"key":"e_1_2_12_67_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19991126)87:3<207::AID-AJMG3>3.0.CO;2-5"},{"key":"e_1_2_12_68_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.5.2439"},{"key":"e_1_2_12_69_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.82.23.8227"},{"key":"e_1_2_12_70_1","first-page":"61","article-title":"Ciclopia completa arinencefalica associata a toxoplasmosi congenita","volume":"11","author":"Grampa G","year":"1961","journal-title":"Folia Hered Pathol"},{"key":"e_1_2_12_71_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(20000214)90:4<328::AID-AJMG13>3.0.CO;2-F"},{"key":"e_1_2_12_72_1","first-page":"A32","article-title":"Mutations in the transcription factor TGIF in holoprosencephaly [abstract]","volume":"63","author":"Gripp KW","year":"1998","journal-title":"Am J Hum Genet"},{"key":"e_1_2_12_73_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1995.tb00995.x"},{"key":"e_1_2_12_74_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1993.tb00805.x"},{"key":"e_1_2_12_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(00)01538-X"},{"key":"e_1_2_12_76_1","unstructured":"GruskinDJ GarberA RimoinDL LachmanRS KelleyRI WilcoxWR.2001.New skeletal dysplasia with sterol abnormalities and defective cytokines in four male siblings. XXII David W. Smith Workshop on Malformation and Morphogenesis. UCLA Conference Center Lake Arrowhead CA September7\u201312."},{"key":"e_1_2_12_77_1","first-page":"209","article-title":"Metodo combinato della suscettibilit\u00e0 differenziale e dei colori vitali per lo studio embrionale degli anfibi","volume":"5","author":"Guareschi C","year":"1934","journal-title":"Reale Accad d'Ital Mem Cl Sci Fis Math e Nat T"},{"key":"e_1_2_12_78_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.13.23.3106"},{"key":"e_1_2_12_79_1","unstructured":"HannoverA.1884.Der Menneskelige Hjerneskals Bygning ved Cyklopie Kj\u00f8benhavn Biano Lunos."},{"key":"e_1_2_12_80_1","doi-asserted-by":"publisher","DOI":"10.1002\/1096-8628(20001002)94:4<341::AID-AJMG14>3.0.CO;2-N"},{"key":"e_1_2_12_81_1","doi-asserted-by":"crossref","first-page":"2803","DOI":"10.1242\/dev.125.15.2803","article-title":"The Shh pathway in tooth development: defects in Gli2 and Gli3 mutants","volume":"125","author":"Hardcastle Z","year":"1998","journal-title":"Development"},{"key":"e_1_2_12_82_1","first-page":"1607","article-title":"ADH4\u2010lacZ transgenic mouse reveals alcohol dehydrogenase localization in embryonic midbrain\/hindbrain, otic vesicles, and mesencephalic, trigeminal, facial, and olfactory neural crest","volume":"227","author":"Haselbeck RJ","year":"1998","journal-title":"Alcohol Clin Exp Res"},{"key":"e_1_2_12_83_1","doi-asserted-by":"publisher","DOI":"10.1038\/350339a0"},{"key":"e_1_2_12_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-3806(00)00032-8"},{"key":"e_1_2_12_85_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.140218797"},{"key":"e_1_2_12_86_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1997.8589"},{"key":"e_1_2_12_87_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970080909"},{"key":"e_1_2_12_88_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.91.5.915"},{"key":"e_1_2_12_89_1","doi-asserted-by":"crossref","first-page":"610","DOI":"10.2337\/diab.32.7.610","article-title":"Effects of maternal diabetes on early embryogenesis: alterations in morphogenesis produced by the ketone body, \u03b2\u2010hydroxybutyrate","volume":"32","author":"Horton WE","year":"1983","journal-title":"Diabetes"},{"key":"e_1_2_12_90_1","doi-asserted-by":"publisher","DOI":"10.1002\/1096-8628(20001002)94:4<300::AID-AJMG7>3.0.CO;2-3"},{"key":"e_1_2_12_91_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.287.5455.1056"},{"key":"e_1_2_12_92_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.125.18.3553"},{"key":"e_1_2_12_93_1","doi-asserted-by":"publisher","DOI":"10.1080\/00039896.1962.10663253"},{"key":"e_1_2_12_94_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00691523"},{"key":"e_1_2_12_95_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420460302"},{"key":"e_1_2_12_96_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420030210"},{"key":"e_1_2_12_97_1","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-149-38794"},{"key":"e_1_2_12_98_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02533750"},{"key":"e_1_2_12_99_1","doi-asserted-by":"publisher","DOI":"10.1139\/o66-101"},{"key":"e_1_2_12_100_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420010103"},{"key":"e_1_2_12_101_1","doi-asserted-by":"publisher","DOI":"10.1086\/301987"},{"key":"e_1_2_12_102_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0065-3101(23)00093-2","article-title":"Inborn errors of cholesterol biosynthesis","volume":"47","author":"Kelley RI","year":"2000","journal-title":"Adv Pediatr"},{"key":"e_1_2_12_103_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19961230)66:4<478::AID-AJMG22>3.0.CO;2-Q"},{"key":"e_1_2_12_104_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19990319)83:3<213::AID-AJMG15>3.0.CO;2-C"},{"key":"e_1_2_12_105_1","first-page":"116","article-title":"Abnormal metabolism of 14\u2010dehydrosterols in hydrops\u2010ectopic calcification\u2010moth\u2010eaten skeletal dysplasia: evidence for new defect of cholesterol biosynthesis","volume":"19","author":"Kelley RI","year":"2000","journal-title":"Proc Greenwood Genet Ctr"},{"key":"e_1_2_12_106_1","unstructured":"KelleyRI KratzLE ShultzLD SundbergJP.2000b.Abnormal sterol metabolism in the flaky skin (fsn) mouse a genetic model for human psoriasis. XXI David W. Smith Workshop on Malformation and Morphogenesis University of California\u2013San Diego School of Medicine La Jolla CA August2\u20135."},{"key":"e_1_2_12_107_1","unstructured":"KelleyRI GlaserRL NetzloffML MillerL WolfMS JabsEW.2001.Abnormal sterol metabolism in a patient with Antley\u2010Bixler syndrome and ambiguous genitalia. XXII David W. Smith Workshop on Malformation and Morphogenesis. UCLA Conference Center Lake Arrowhead CA September7\u201312."},{"key":"e_1_2_12_108_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1000200307"},{"key":"e_1_2_12_109_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00281113"},{"key":"e_1_2_12_110_1","first-page":"120","article-title":"Cyclopia","volume":"125","author":"Khudr G","year":"1973","journal-title":"Am J Dis Child"},{"key":"e_1_2_12_111_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1991.03460060063025"},{"key":"e_1_2_12_112_1","first-page":"246","article-title":"\u00dcber die Arhinenzephalie","volume":"88","author":"K\u00f6hn K","year":"1952","journal-title":"Zbl allg Path path Anat"},{"key":"e_1_2_12_113_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9926(199609)54:3<115::AID-TERA1>3.0.CO;2-2"},{"key":"e_1_2_12_114_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9926(199709)56:3<188::AID-TERA2>3.0.CO;2-Y"},{"key":"e_1_2_12_115_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19990423)83:5<402::AID-AJMG12>3.0.CO;2-F"},{"key":"e_1_2_12_116_1","first-page":"136","article-title":"Holoprosencephaly in a fetus with maternal medication of sulfasalazine in early gestation","volume":"23","author":"Koyama N","year":"1996","journal-title":"Clin Exp Obstet Gynecol"},{"key":"e_1_2_12_117_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198510033131401"},{"key":"e_1_2_12_118_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02982778"},{"key":"e_1_2_12_119_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19971128)73:1<24::AID-AJMG6>3.0.CO;2-P"},{"key":"e_1_2_12_120_1","first-page":"251","article-title":"Die Augen\u2010 und Linsenbildung von Amphibien\u2010embryonen unter dem Einfluss chemischer Mittel","volume":"40","author":"Lehmann FE","year":"1933","journal-title":"Rev Suisse Zool"},{"key":"e_1_2_12_121_1","first-page":"230","article-title":"Production artificielle de t\u00e9tards cyclops et anophthalmes","volume":"4","author":"LePlat G","year":"1913","journal-title":"Ann Soc de M\u00e9d de Gand ns"},{"key":"e_1_2_12_122_1","first-page":"280","article-title":"Localisation des premi\u00e8res \u00e9bauches oculaires chez les vert\u00e9br\u00e9s. Pathog\u00e9nie de la cyclopie","volume":"46","author":"LePlat G","year":"1914","journal-title":"Anat Anz"},{"key":"e_1_2_12_123_1","first-page":"231","article-title":"Action du milieu sur le developpement des larves d'amphibiens. Localisation et diff\u00e9renciation des premi\u00e8res \u00e9bauches oculaires chez les vert\u00e9br\u00e9s. Cyclopie et anophthalmie","volume":"30","author":"LePlat G","year":"1919","journal-title":"Arch Biol"},{"key":"e_1_2_12_124_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1090030406"},{"key":"e_1_2_12_125_1","first-page":"32","article-title":"The cyclops deformity. Case report","volume":"61","author":"Lillard RL","year":"1964","journal-title":"Rocky Mtn Med J"},{"key":"e_1_2_12_126_1","first-page":"25","article-title":"Arhinencephalia: considerations \u00e0 propos a case diagnosed during life","volume":"67","author":"Lison MP","year":"1967","journal-title":"Acta Neurol Belg"},{"key":"e_1_2_12_127_1","doi-asserted-by":"publisher","DOI":"10.2307\/1536260"},{"key":"e_1_2_12_128_1","first-page":"129","article-title":"Alcohol embryopathy: some facts and speculations about pathogenesis","volume":"3","author":"Majewski F","year":"1981","journal-title":"Neurol Toxicol Teratol"},{"key":"e_1_2_12_129_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-91062-3_4"},{"key":"e_1_2_12_130_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0014-2956.2001.02416.x-i2"},{"key":"e_1_2_12_131_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320510206"},{"key":"e_1_2_12_132_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19980630)78:2<140::AID-AJMG8>3.0.CO;2-S"},{"key":"e_1_2_12_133_1","first-page":"295","article-title":"Teratogenic potentially of single dose of thalidomide in JW\u2010NIBS rabbits [Japanese]","volume":"34","author":"Matsubara Y","year":"1985","journal-title":"Jikken\u2010Dobutsu"},{"key":"e_1_2_12_134_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420160304"},{"key":"e_1_2_12_135_1","first-page":"189","article-title":"An attempt toward the physical chemistry of the production of one\u2010eyed monstrosities","volume":"19","author":"McClendon JF","year":"1912","journal-title":"Am J Phys"},{"key":"e_1_2_12_136_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0741-8329(00)00132-4"},{"key":"e_1_2_12_137_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.1998.tb02666.x"},{"key":"e_1_2_12_138_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420280316"},{"key":"e_1_2_12_139_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.4.1899"},{"key":"e_1_2_12_140_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.1979.tb00854.x"},{"key":"e_1_2_12_141_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970070905"},{"key":"e_1_2_12_142_1","first-page":"6203","volume-title":"The metabolic and molecular basis of inherited disease","author":"Muenke M","year":"2001"},{"key":"e_1_2_12_143_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2779(2000)6:1<15::AID-MRDD3>3.0.CO;2-8"},{"key":"e_1_2_12_144_1","unstructured":"MuenkeM de la CruzJ BamfordRN RoesslerE KarkeraJ KantipongA BurdineRD SchierAF TowbinJA BowersP GoldmuntzE DonnaiD.2001.Genetic mechanisms underlying midline and laterality defects. XXII David W. Smith Workshop on Malformations and Morphogenesis UCLA Conference Center Lake Arrowhead CA September7\u201312."},{"key":"e_1_2_12_145_1","first-page":"64","article-title":"Radiation malformations belonging to the cyclopia\u2010otocephalia group in the mouse foetus","volume":"10","author":"Murakami V","year":"1962","journal-title":"J Embryol Exp Morphol"},{"key":"e_1_2_12_146_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/8.13.2479"},{"key":"e_1_2_12_147_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.290.5500.2298"},{"key":"e_1_2_12_148_1","first-page":"213","article-title":"Congenital malformation in offspring of diabetics","volume":"8","author":"Neave C","year":"1984","journal-title":"Perspect Pediatr Pathol"},{"key":"e_1_2_12_149_1","doi-asserted-by":"publisher","DOI":"10.1038\/31693"},{"key":"e_1_2_12_150_1","first-page":"3383","article-title":"Environmental agents that have the potential to trigger massive apoptotic neurodegeneration in the developing brain","volume":"108","author":"Olney JW","year":"2000","journal-title":"Environ Health Perspect"},{"key":"e_1_2_12_151_1","first-page":"21","article-title":"Effects of prenatal ethanol exposure on neuronal migration; neuronogenesis and brain myelination in the mice","volume":"19","author":"Ozer E","year":"2000","journal-title":"Clin Neuropathol"},{"key":"e_1_2_12_152_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.22.14037"},{"key":"e_1_2_12_153_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(79)90033-9"},{"key":"e_1_2_12_154_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.274.5285.255"},{"key":"e_1_2_12_155_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-48757-6"},{"key":"e_1_2_12_156_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19961218)66:3<320::AID-AJMG16>3.0.CO;2-O"},{"key":"e_1_2_12_157_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1998.8935"},{"key":"e_1_2_12_158_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.17.9932"},{"key":"e_1_2_12_159_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9926(199610)54:4<171::AID-TERA1>3.0.CO;2-4"},{"key":"e_1_2_12_160_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1005406719292"},{"key":"e_1_2_12_161_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1196-357"},{"key":"e_1_2_12_162_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/6.11.1847"},{"key":"e_1_2_12_163_1","first-page":"195","article-title":"Methanol causes the holoprosencephaly spectrum of malformations at lower dosages than ethanol in C57BL\/6J mice (abstract)","volume":"51","author":"Rogers JM","year":"1995","journal-title":"Teratology"},{"key":"e_1_2_12_164_1","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(63)90038-1"},{"key":"e_1_2_12_165_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001150306"},{"key":"e_1_2_12_166_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320420129"},{"key":"e_1_2_12_167_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320400206"},{"key":"e_1_2_12_168_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420510405"},{"key":"e_1_2_12_169_1","first-page":"61","volume-title":"Teratogen update: environmentally induced birth defect risks","author":"Rosa FW","year":"1986"},{"key":"e_1_2_12_170_1","first-page":"418","article-title":"Holoprosencephaly with 1st trimester topical tretinoin","volume":"49","author":"Rosa F","year":"1994","journal-title":"Teratology"},{"key":"e_1_2_12_171_1","first-page":"451","article-title":"Action teratogenie du triparanol chez l'animal","volume":"21","author":"Roux C","year":"1964","journal-title":"Arch Fran\u00e7 P\u00e9diatr"},{"key":"e_1_2_12_172_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320550323"},{"key":"e_1_2_12_173_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-999717"},{"key":"e_1_2_12_174_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.38.1.70"},{"key":"e_1_2_12_175_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1993.tb26109.x"},{"key":"e_1_2_12_176_1","doi-asserted-by":"publisher","DOI":"10.1038\/26020"},{"key":"e_1_2_12_177_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02255980"},{"key":"e_1_2_12_178_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(97)70035-8"},{"key":"e_1_2_12_179_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.124.2.327"},{"key":"e_1_2_12_180_1","first-page":"255","article-title":"Obtention exp\u00e9rimentale de cyclopes parfaits par microchirrurgie chez l'embryon de poulet, \u00e9tude histologique","volume":"14","author":"Schowing J","year":"1965","journal-title":"J Embryol Exp Morphol"},{"key":"e_1_2_12_181_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(66)80462-6"},{"key":"e_1_2_12_182_1","first-page":"251","article-title":"The role of alcohol dehydrogenase in retinoic acid homeostasis and fetal alcohol syndrome","volume":"173","author":"Shean ML","year":"1993","journal-title":"Alcohol Clin Exp Res"},{"key":"e_1_2_12_183_1","volume-title":"Holoprosencephaly. An overview and atlas of cases","author":"Siebert JR","year":"1990"},{"key":"e_1_2_12_184_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420440106"},{"key":"e_1_2_12_185_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.290.5497.1721"},{"key":"e_1_2_12_186_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1999.9370"},{"key":"e_1_2_12_187_1","first-page":"429","article-title":"\u00dcber experimentellerzeugte Doppelbildungen mit cyclopischem Defekt","volume":"7","author":"Spemann H","year":"1904","journal-title":"Zool Jahrb"},{"key":"e_1_2_12_188_1","first-page":"147","article-title":"A case of suspected teratogenic holoprosencephaly","volume":"21","author":"Stabile M","year":"1984","journal-title":"J Med Genet"},{"key":"e_1_2_12_189_1","first-page":"149","article-title":"The artificial production of a single, median cyclopean eye in the fish embryo by means of sea water solutions of magnesium chloride","volume":"23","author":"Stockard CR","year":"1907","journal-title":"Arch f Entmeth"},{"key":"e_1_2_12_190_1","doi-asserted-by":"publisher","DOI":"10.1002\/jez.1400040202"},{"key":"e_1_2_12_191_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.28.718.455"},{"key":"e_1_2_12_192_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1090030405"},{"key":"e_1_2_12_193_1","doi-asserted-by":"publisher","DOI":"10.1002\/jez.1400060205"},{"key":"e_1_2_12_194_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1000100110"},{"key":"e_1_2_12_195_1","first-page":"473","article-title":"The experimental production of various eye abnormalities and an analysis of the development of the primary parts of the eye","volume":"1","author":"Stockard CR","year":"1910","journal-title":"Arch vergl Ophth"},{"key":"e_1_2_12_196_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1090080202"},{"key":"e_1_2_12_197_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4624.1997.00010.x"},{"key":"e_1_2_12_198_1","first-page":"309","article-title":"Embryonic origin of holoprosencephaly: interrelationship of the developing brain and face","volume":"1","author":"Sulik KK","year":"1982","journal-title":"Scan Electron Microsc"},{"key":"e_1_2_12_199_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420510605"},{"key":"e_1_2_12_200_1","volume-title":"Storia della teratologia","author":"Taruffi C","year":"1881"},{"key":"e_1_2_12_201_1","doi-asserted-by":"publisher","DOI":"10.1097\/00019605-199407000-00015"},{"key":"e_1_2_12_202_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1999.9421"},{"key":"e_1_2_12_203_1","doi-asserted-by":"publisher","DOI":"10.1006\/mgme.1999.2895"},{"key":"e_1_2_12_204_1","doi-asserted-by":"publisher","DOI":"10.1038\/9718"},{"key":"e_1_2_12_205_1","doi-asserted-by":"publisher","DOI":"10.1086\/301936"},{"key":"e_1_2_12_206_1","doi-asserted-by":"publisher","DOI":"10.1086\/301982"},{"key":"e_1_2_12_207_1","doi-asserted-by":"publisher","DOI":"10.1086\/323473"},{"key":"e_1_2_12_208_1","volume-title":"Human metabolism of alcohol","author":"Webster WS","year":"1983"},{"key":"e_1_2_12_209_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320470613"},{"key":"e_1_2_12_210_1","first-page":"258","article-title":"Blastolysis as a morphogenetic factor in the development of monsters","volume":"10","author":"Werber EI","year":"1916","journal-title":"Anat Rec"},{"key":"e_1_2_12_211_1","doi-asserted-by":"publisher","DOI":"10.1002\/jez.1400210404"},{"key":"e_1_2_12_212_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.16.8460"},{"key":"e_1_2_12_213_1","doi-asserted-by":"publisher","DOI":"10.1086\/302760"},{"key":"e_1_2_12_214_1","first-page":"145","article-title":"Recherches exp\u00e9rimentales sur la cyclopie","volume":"18","author":"Wolff E","year":"1934","journal-title":"Arch Anat Histol Embryol"},{"key":"e_1_2_12_215_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1000540303"},{"key":"e_1_2_12_216_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-195901000-00003"},{"key":"e_1_2_12_217_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/9.9.1385"},{"key":"e_1_2_12_218_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1998.tb03948.x"},{"key":"e_1_2_12_219_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80918-6"}],"container-title":["American Journal of Medical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajmg.10258","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajmg.10258","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,2]],"date-time":"2024-12-02T15:26:31Z","timestamp":1733153191000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajmg.10258"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,3,22]]},"references-count":218,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2002,4,15]]}},"alternative-id":["10.1002\/ajmg.10258"],"URL":"https:\/\/doi.org\/10.1002\/ajmg.10258","archive":["Portico"],"relation":{},"ISSN":["0148-7299","1096-8628"],"issn-type":[{"value":"0148-7299","type":"print"},{"value":"1096-8628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,3,22]]}}}