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As expected, the highest risk for UPD was found in cases with translocations between homologous acrocentric chromosomes (11 cases with UPD of 15 investigated) and in CPM due to a meiotic error (25 of 51 cases).<\/jats:p><jats:p>In prenatal investigations or in cases with a normal phenotype, translocations between nonhomologous acrocentric chromosomes implied a risk for UPD of less than 0.5%. The risks for maternal UPD 7 in cases with SRS\/PGR, for UPD 15 in cases with an additional inv dup(15) marker chromosome, and for UPD of any chromosome in cases with multiple malformation\/mental retardation were approximately 5.5%, and approximately 1.3%, respectively. Searches for UPD in well\u2010defined syndromes (Brachmann\u2010De Lange syndrome, Sotos syndrome, Rett syndrome, Weaver syndrome, or XX true hermaphroditism) were disappointing. Not a single case was found. \u00a9 2002 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.10569","type":"journal-article","created":{"date-parts":[[2002,9,5]],"date-time":"2002-09-05T20:26:02Z","timestamp":1031257562000},"page":"366-375","source":"Crossref","is-referenced-by-count":35,"title":["Review and meta\u2010analysis of systematic searches for uniparental disomy (UPD) other than UPD 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