{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T22:12:07Z","timestamp":1715983927312},"reference-count":50,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2002,7,10]],"date-time":"2002-07-10T00:00:00Z","timestamp":1026259200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Med. Genet."],"published-print":{"date-parts":[[2002,8,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>There is evidence from animal experiments that the \u03bc\u2010 and \u03b4\u2010opioid receptors may play a role in anxiety and depression. It might therefore be expected that functional polymorphisms of these genes in humans are associated with anxiety and depression. We investigated a single\u2010nucleotide polymorphism (Asn40Asp) of the \u03bc\u2010opioid receptor gene (OPRM1). This association was investigated in two samples: 1) a cross\u2010sectional survey of 867 community\u2010living adults aged 18\u201379 years who were assessed for anxiety and depression symptoms and related personality traits; and 2) a longitudinal study of childhood temperament in which 660 children were followed from infancy to the mid\u2010teens and assessed for anxiety\u2010related temperament and behavior problems. The data did not support a role for the Asn40Asp polymorphism in anxiety and depression, despite adequate statistical power to detect small effects. \u00a9 2002 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.10643","type":"journal-article","created":{"date-parts":[[2002,10,6]],"date-time":"2002-10-06T11:56:23Z","timestamp":1033905383000},"page":"659-664","source":"Crossref","is-referenced-by-count":16,"title":["Lack of association of a single\u2010nucleotide polymorphism of the \u03bc\u2010opioid receptor gene with anxiety\u2010related traits: Results from a cross\u2010sectional study of adults and a longitudinal study of children"],"prefix":"10.1002","volume":"114","author":[{"given":"Anthony F.","family":"Jorm","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margot","family":"Prior","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ann","family":"Sanson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana","family":"Smart","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yafei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan","family":"Tan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon","family":"Easteal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2002,10,23]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/016502549501800403"},{"key":"e_1_2_6_3_1","volume-title":"Diagnostic and statistical manual for mental disorders","author":"American Psychiatric Association","year":"1987"},{"key":"e_1_2_6_4_1","first-page":"237","article-title":"Development of a short questionnaire for use in epidemiological studies of depression in children and adolescents","volume":"5","author":"Angold A","year":"1995","journal-title":"Int J Meth Psychiatr Res"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0191-8869(96)00242-5"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0191-8869(98)00237-2"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M006352200"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1037\/h0037058"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4000331"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.16.9608"},{"key":"e_1_2_6_11_1","volume-title":"Temperament: early developing personality traits","author":"Buss AH","year":"1984"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1037\/0022-3514.67.2.319"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291798008150"},{"key":"e_1_2_6_14_1","first-page":"93","volume-title":"Statistical power analysis for the behavioral sciences","author":"Cohen J","year":"1988"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0191-8869(85)90026-1"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/76061"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/1096-8628(20010108)105:1<114::AID-AJMG1074>3.0.CO;2-L"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/jpepsy\/9.2.205"},{"key":"e_1_2_6_19_1","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1037\/0022-3514.78.6.1135","article-title":"Behavioral activation and inhibition in everyday life","volume":"78","author":"Gable SL","year":"2000","journal-title":"J Pers Soc Psychol"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4000556"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.297.6653.897"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1027\/1015-5759.13.3.179"},{"key":"e_1_2_6_23_1","first-page":"171","volume-title":"Cognitive neurochemistry","author":"Gray JA","year":"1987"},{"key":"e_1_2_6_24_1","first-page":"27","article-title":"Five exon 1 variants of mu opioid receptor and vulnerability to alcohol dependence","volume":"52","author":"Gscheidel N","year":"2000","journal-title":"Pol J Pharmacol"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/9.19.2895"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001270050001"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4000424"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0191-8869(98)00143-3"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4000782"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(99)00137-7"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7610.1997.tb01543.x"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1177\/0164027592142001"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291700029068"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/0191-8869(95)00011-T"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0191-8869(98)00251-7"},{"key":"e_1_2_6_36_1","first-page":"271","article-title":"The development of the school\u2010age temperament inventory","volume":"41","author":"McClowry SG","year":"1995","journal-title":"Merrill\u2010Palmer Q"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/0278-5846(88)90076-0"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19991215)88:6<657::AID-AJMG15>3.0.CO;2-#"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1177\/016502548701000108"},{"key":"e_1_2_6_40_1","volume-title":"Pathways from infancy to adolescence: Australian Temperament Project 1983\u20132000","author":"Prior M","year":"2000"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004583-200004000-00015"},{"key":"e_1_2_6_42_1","volume-title":"Manual for the revised behavior problem checklist","author":"Quay HC","year":"1987"},{"key":"e_1_2_6_43_1","volume-title":"Revised children's manifest anxiety scale","author":"Reynolds CR","year":"1985"},{"key":"e_1_2_6_44_1","volume-title":"Education, health and behaviour","author":"Rutter M","year":"1970"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1998.tb05923.x"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1080\/00049538508256397"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/0163-6383(87)90009-9"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-200105080-00011"},{"key":"e_1_2_6_49_1","volume-title":"Temperament and development","author":"Thomas A","year":"1977"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19991015)88:5<458::AID-AJMG3>3.0.CO;2-S"},{"key":"e_1_2_6_51_1","volume-title":"The PANAS\u2010X: manual for the positive and negative affect schedule\u2014expanded form","author":"Watson D","year":"1994"}],"container-title":["American Journal of Medical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajmg.10643","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajmg.10643","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T14:43:56Z","timestamp":1696949036000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajmg.10643"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,8,8]]},"references-count":50,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2002,8,8]]}},"alternative-id":["10.1002\/ajmg.10643"],"URL":"https:\/\/doi.org\/10.1002\/ajmg.10643","archive":["Portico"],"relation":{},"ISSN":["0148-7299","1096-8628"],"issn-type":[{"value":"0148-7299","type":"print"},{"value":"1096-8628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,8,8]]}}}