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In 74 families, there was evidence of an affected parent, 49 maternal and 25 paternal. Genome scan data were analyzed for the sample as a whole and for the maternal and paternal families separately, using Genehunter\u2010ASM. Seven regions with Z<jats:sub>lr<\/jats:sub> scores \u22652 were identified, four in maternal families (chr. 10,12,19,20) and three in paternal families (chr. 1,7,13). With the exception of the chromosome 10 finding, analysis by parent of origin greatly increased evidence of linkage in areas showing no linkage in the overall analyses. For example, a chr. 12 region reached a LOD\u2009=\u20092.29 among maternal families whereas the same region showed a LOD\u2009=\u20090.3 when all families were analyzed together. The strongest findings among maternal families (chr. 10 and 12) were followed up with fine mapping that resulted in an increase in maximum LOD scores from 2.7\u20133.2 on chr. 10, and 2.29\u20132.42 on chr. 12. These analyses highlight the importance of parent of origin effects in late\u2010onset AD families and identify several genomic regions that may include genes linked to late\u2010onset AD specific to disease transmission from the mother and require further investigation. \u00a9 2002 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.10648","type":"journal-article","created":{"date-parts":[[2002,10,6]],"date-time":"2002-10-06T11:56:23Z","timestamp":1033905383000},"page":"679-686","source":"Crossref","is-referenced-by-count":51,"title":["Evidence for parent of origin effect in late\u2010onset Alzheimer disease"],"prefix":"10.1002","volume":"114","author":[{"given":"Susan Spear","family":"Bassett","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrios","family":"Avramopoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Fallin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2002,10,23]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320600102"},{"key":"e_1_2_6_3_1","unstructured":"BlackerD BertramL SaundersAJ MoscarilloTJ AlbertMS WienerH PerryR GoRCP MahoneyA BeatyT FallinMD BassettSS PughEW DohenyKF TanziRE.2001Results of a hight resolution genome screen in 443 alzheimer disease families: the NIMH genetics initiative. 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