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While CLL's etiology remains elusive, there is increasing evidence that substantially supports the role of hereditary factors in a subset of cases of this disease. Our purpose is to describe an extremely well documented CLL family wherein the disease has been verified in a father and his four sons; two of the sons are identical twins. The family history, including available medical records and pathology reports, was gathered and reviewed. Peripheral blood lymphocytes were used for cytogenetic and fluorescence in situ hybridization analyses. The family reported herein shows classic findings in support of an autosomal dominant mode of genetic transmission of CLL. Given the explosive developments in molecular genetics during the past decade, it is certain that families of this type will provide important clues to the etiology, pathogenesis, and ultimate prevention of CLL. \u00a9 2002 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.10686","type":"journal-article","created":{"date-parts":[[2002,10,30]],"date-time":"2002-10-30T14:15:26Z","timestamp":1035987326000},"page":"113-117","source":"Crossref","is-referenced-by-count":11,"title":["Hereditary chronic lymphocytic leukemia: An extended family study and literature review"],"prefix":"10.1002","volume":"115","author":[{"given":"Henry T.","family":"Lynch","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis D.","family":"Weisenburger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigid","family":"Quinn\u2010Laquer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrice","family":"Watson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane F.","family":"Lynch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Warren G.","family":"Sanger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2002,7,15]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"3982","article-title":"Linkage analysis for major histocompatibility complex\u2013related genetic susceptibility in familial chronic lymphocytic leukemia","volume":"96","author":"Bevan S","year":"2000","journal-title":"Blood"},{"key":"e_1_2_5_3_1","article-title":"Cytogenetic characterization of diffuse large cell lymphoma using M\u2010FISH","author":"Bhavana DJ","journal-title":"Cancer Genet Cytogenet"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0609.2000.90183.x"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1987.158"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200012283432602"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200104053441402"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200104053441401"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2400874"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng763"},{"key":"e_1_2_5_11_1","first-page":"209","article-title":"Biology of chronic lymphocytic leukemia","volume":"24","author":"Gale RP","year":"1987","journal-title":"Semin Hematol"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1086\/302458"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng755"},{"key":"e_1_2_5_14_1","volume-title":"Chronic lymphocytic leukemia. 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