{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T05:54:26Z","timestamp":1759730066912},"reference-count":38,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,6,3]],"date-time":"2005-06-03T00:00:00Z","timestamp":1117756800000},"content-version":"vor","delay-in-days":10015,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Med. Genet."],"published-print":{"date-parts":[[1978,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Chromosomes from four patients with variants of the Turner syndrome were investigated by G\u2010 and C\u2010 banding and DNA replication techniques. Their karyotypes were: 1) 46,X,idic(X)(q28), 2) 45,X\/46,X,idic(X)(q24), 3)45,X\/ 46,X,idic(X)(p11), and 4) 46,X,i(Xq). In Patients 1, 2, and 3, the abnormal X was isodicentric, with different break\u2010and\u2010fusion points in each case. In each, the G\u2010band pattern on one side of the breakpoint was a mirror image of that on the other side. Each had two distinct C\u2010bands, only one of which was associated with a primary constriction. The fourth patient had an isochromosome of the long arm of an X in which only one C\u2010band could be discerned. Replication studies were done on lymphocyte cultures by incorporating a thymidine analogue and staining with acridine orange. In addition, replication patterns of normal early\u2010 and late\u2010replicating X chromosomes were studied in two normal females. In the four patients, all the normal X chromosomes had normal early\u2010replication patterns. The two idic(X) chromosomes with break\u2010and\u2010fusion points on their long arms almost always had symmetric replication patterns, which demonstrates that the corresponding bands replicated synchronously. In contrast, many of the idic(X)(p11) and i(Xq) chromosomes showed asymmetric or asynchronous replication. In each, the replication pattern of the abnormal X was similar to the equivalent portions of a normal late\u2010replicating X.<\/jats:p>","DOI":"10.1002\/ajmg.1320010407","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T17:27:51Z","timestamp":1118510871000},"page":"445-460","source":"Crossref","is-referenced-by-count":24,"title":["Replication patterns of three isodicentric X chromosomes and an X isochromosome in human lymphocytes"],"prefix":"10.1002","volume":"1","author":[{"given":"Gordon","family":"Dewald","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jack 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