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A normal sister who had the same balanced chromosome translocation was evaluated for a preleukemic state; the results were unremarkable. The inherited translocation and postzygotically derived trisomy 8 are thought to represent additive factors contributing to the development of leukemia in the patient.<\/jats:p>","DOI":"10.1002\/ajmg.1320020104","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T17:28:41Z","timestamp":1118510921000},"page":"15-21","source":"Crossref","is-referenced-by-count":30,"title":["Acute leukemia associated with trisomy 8 mosaicism and a familial translocation 46,XY,t(7;20)(p13;p12)"],"prefix":"10.1002","volume":"2","author":[{"given":"Vincent M.","family":"Riccardi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James R.","family":"Humbert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Peakman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Herrmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,6,2]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.959840"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.72.1.152"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(76)91076-X"},{"key":"e_1_2_1_5_2","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1542\/peds.61.4.604","article-title":"Chromosomal imbalance in the aniridia\u2010Wilms tumor association: 11p interstitial deletion","volume":"61","author":"Riccardi VM","year":"1978","journal-title":"Pediatrics"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/mpo.2950020404"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197611112952007"},{"key":"e_1_2_1_8_2","first-page":"1","article-title":"Application of new staining techniques to the study of human chromosomes","volume":"9","author":"Miller OJ","year":"1973","journal-title":"Prog Med Genet"},{"key":"e_1_2_1_9_2","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1128\/jvi.6.6.738-749.1970","article-title":"Change in deoxyribonucleic acid synthesis regulation in Chinese hamster cells infected with Simian Virus 40","volume":"6","author":"Lehman JM","year":"1970","journal-title":"J Virol"},{"key":"e_1_2_1_10_2","unstructured":"HumbertJR MorseHG HutterJJ RoseB RobinsonA: Non\u2010leukemia dividing cells in the blood of leukemic patients. 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