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The other two had no stridor, aspiration, or difficulty swallowing, and were considered to have the BBB syndrome. Both disorders are associated with multiple malformations and can be most readily distinguished by the presence of laryngoesophageal abnormalities in the G syndrome and differences in facial features evident later in childhood. The BBB syndrome appears to be inherited as an X\u2010linked disorder with the affected female showing only telecanthus and hypertelorism. The G syndrome exhibits autosomal dominant inheritance with males more severely affected, although a few few females have had serious malformations in addition to telecanthus and hypertelorism. In the family with the G syndrome evaluated for this report, the mother of the affected infant had telecanthus, hypertelorism, and anosmia, the latter a feature not previously noted in this disorder.<\/jats:p>","DOI":"10.1002\/ajmg.1320020205","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T17:28:50Z","timestamp":1118510930000},"page":"145-152","source":"Crossref","is-referenced-by-count":57,"title":["Phenotypic overlap of the BBB and G syndromes"],"prefix":"10.1002","volume":"2","author":[{"given":"Jos\u00e9 F.","family":"Cordero","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lewis B.","family":"Holmes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John M.","family":"Opitz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,2]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(65)81932-1"},{"key":"e_1_2_1_3_2","volume-title":"Malformation Syndromes, Part II","author":"Christian JC"},{"issue":"2","key":"e_1_2_1_3_3","first-page":"82","year":"1969","journal-title":"BD:OAS"},{"key":"e_1_2_1_4_2","volume-title":"Malformation Syndromes, Part II","author":"Opitz JM"},{"issue":"2","key":"e_1_2_1_4_3","first-page":"86","year":"1969","journal-title":"BD:OAS"},{"key":"e_1_2_1_5_2","first-page":"575","article-title":"Association of hypertelorism and hypospadias \u2010 the BBB syndrome","volume":"27","author":"Michaelis E","year":"1972","journal-title":"Helv Paediatr Acta"},{"key":"e_1_2_1_6_2","first-page":"240","article-title":"The hypertelorism\u2010hypospadias syndrome","volume":"26","author":"Reed MH","year":"1975","journal-title":"J Can Assoc Radiol"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00470600"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-197404000-00610"},{"key":"e_1_2_1_9_2","volume-title":"Malformation Syndromes, Part II","author":"Opitz JM"},{"issue":"2","key":"e_1_2_1_9_3","first-page":"95","year":"1969","journal-title":"BD:OAS"},{"key":"e_1_2_1_10_2","first-page":"466","article-title":"G syndrome","volume":"120","author":"Coburn TP","year":"1970","journal-title":"Am J Dis Ch"},{"key":"e_1_2_1_11_2","first-page":"505","article-title":"The G syndrome","volume":"121","author":"Little JR","year":"1971","journal-title":"Am J Dis Child"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00438596"},{"key":"e_1_2_1_13_2","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/BF00440023","article-title":"Studies of malformation syndromes VID: The G syndrome: Further observations","volume":"118","author":"Kasner J","year":"1974","journal-title":"Z Kinderheilk"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.1975.tb00325.x"},{"key":"e_1_2_1_15_2","volume-title":"Malformation Syndromes (1972 Birth Defects Conference)","author":"Frias JL"},{"issue":"2","key":"e_1_2_1_15_3","first-page":"54","year":"1975","journal-title":"BD: OAS"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1159\/000152784"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(69)80206-4"},{"key":"e_1_2_1_18_2","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1542\/peds.44.6.973","article-title":"Objective measurement of interpupillary distance","volume":"44","author":"Pryor HB","year":"1969","journal-title":"Pediatrics"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(63)92325-0"},{"key":"e_1_2_1_20_2","unstructured":"HolmesLB: The Malformed Newborn: Practical Perspectives. 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