{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T15:26:04Z","timestamp":1764602764259},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,6,7]],"date-time":"2005-06-07T00:00:00Z","timestamp":1118102400000},"content-version":"vor","delay-in-days":10019,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Med. Genet."],"published-print":{"date-parts":[[1978,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Eighty normal Caucasians were studied by CBG technique for estimation of size and inversion heteromorphisms of chromosomes 1, 9, and 16. Size heteromorphisms were classified into one of five sizes using 16p as a reference standard: very small, small, intermediate, large, and very large. Inversion heteromorphisms were also classified into 5 categories \u2013 eg, no inversion; partial inversion \u2013 minor; half inversion; partial inversion \u2013 major; and complete inversion. The frequencies of size heteromorphisms for chromosomes 1, 9, and 16 were 11.3%, 47.5%, and 7.5%, respectively. Thirty\u2010four chromosomes were found to have inversions. Of these, 16 were in chromosome 1, and 18 were in chromosome 9. No inversions were found in chromosome 16. An increase in the size of the h region was more frequently associated with inversion, suggesting that there is a possible relationship between size and inversion. For example, there were 118 chromosomes that were classified as \u201cintermediate\u201d by size; 23 (19.5%) had inversions. In contrast, there were 225 that were \u201csmall\u201d in size, and only 10 (4.4%) had inversions. There was no significant difference between males and females for size and position heteromorphisms.<\/jats:p>","DOI":"10.1002\/ajmg.1320020403","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T17:30:52Z","timestamp":1118511052000},"page":"331-339","source":"Crossref","is-referenced-by-count":26,"title":["Size and pericentric inversion heteromorphisms of secondary constriction regions (h) of chromosomes 1, 9, and 16 as detected by CBG technique in Caucasians: Classification, frequencies, and incidence"],"prefix":"10.1002","volume":"2","author":[{"given":"Ram S.","family":"Verma","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harvey","family":"Dosik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Herbert A.","family":"Lubs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uta","family":"Francke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,7]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1159\/000129743"},{"key":"e_1_2_1_3_2","volume-title":"Medical Genetics Today","author":"Ferguson\u2010Smith MA"},{"issue":"10","key":"e_1_2_1_3_3","first-page":"19","author":"National Foundation\u2013March of Dimes","year":"1974","journal-title":"BD:OAS"},{"key":"e_1_2_1_4_2","first-page":"746","article-title":"Pericentric inversion of human chromosome 9 and 10","volume":"26","author":"De la Chapelle A","year":"1974","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00270855"},{"key":"e_1_2_1_6_2","first-page":"431","article-title":"Chromosome Polymorphism and twin zygosity","volume":"29","author":"Van Dyke DL","year":"1977","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1159\/000130330"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1159\/000152820"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.1974.tb02086.x"},{"key":"e_1_2_1_10_2","first-page":"179","volume-title":"Population Cytogenetics","author":"Magenis E","year":"1976"},{"key":"e_1_2_1_11_2","first-page":"179","article-title":"Polymorphism of human C\u2010band heterochromatin. 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