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Some, but not all, patients had laryngeal cleft, abnormal lung lobulation, renal agenesis and\/or renal dysplasia, short 4th metacarpals, nail dysplasia, multiple buccal frenula, hypoadrenalism, microphallus, congential heart defect, and intrauterine growth retardation. The infants also had hypopituitarism and hypoadrenalism.<\/jats:p><jats:p>All were sporadic cases, parents were not consanguineous, chromosomes were apparently normal. Family histories were unremarkable. There was insecticide and\/or herbicide exposure in several of the cases, but no exposures were common to all 6 mothers. Five of the patients were born within an 8\u2010month period, but all in different geographic locations. It is postulated that this is a previously apparently unreported syndrome of presently unknown cause.<\/jats:p>","DOI":"10.1002\/ajmg.1320070110","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T17:37:48Z","timestamp":1118511468000},"page":"47-74","source":"Crossref","is-referenced-by-count":285,"title":["Congenital hypothalamic hamartoblastoma, hypopituitarism, imperforate anus, and postaxial polydactyly\u2014a new syndrome? Part I: Clinical, causal, and pathogenetic considerations"],"prefix":"10.1002","volume":"7","author":[{"given":"J. G.","family":"Hall","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. D.","family":"Pallister","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. K.","family":"Clarren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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