{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T15:58:57Z","timestamp":1790351937718,"version":"4.1.0"},"reference-count":11,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,6,2]],"date-time":"2005-06-02T00:00:00Z","timestamp":1117670400000},"content-version":"vor","delay-in-days":9284,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Med. Genet."],"published-print":{"date-parts":[[1980,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Unusual and virtually identical hypothalamic tumors were recently studied in three unrelated neonates with a similar complex malformation syndrome. Previous reports of either the hypothalamic tumors or the syndrome as a whole have not been found. Each tumor was apparent on the inferior surface of the cerebrum and extended from the optic chiasma to the interpeduncular fossa. The tumor replaced the hypothalamus and other nuclei which originate in the embryonic hypothalamic plate; it was principally composed of cells resembling primitive, undifferentiated germinal cells. The term \u201chamartoblastoma\u201d is used to designate these tumors in order to emphasize the malformational and neoplastic aspects. In addition, short olfactory tracts suggest a relation to the arrhinencephaly field defect.<\/jats:p>","DOI":"10.1002\/ajmg.1320070111","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T17:37:48Z","timestamp":1118511468000},"page":"75-83","source":"Crossref","is-referenced-by-count":76,"title":["Congenital hypothalamic hamartoblastoma, hypopituitarism, imperforate anus, and postaxial polydactyly\u2014a new syndrome? Part II: Neuropathological considerations"],"prefix":"10.1002","volume":"7","author":[{"given":"Sterling K.","family":"Clarren","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Ellsworth C.","family":"Alvord","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith G.","family":"Hall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John M.","family":"Optiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,6,2]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-196104000-00006"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000140439"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000141606"},{"key":"e_1_2_1_5_1","unstructured":"HallJG PallisterPD ClarrenSK BeckwithBJ WiglesworthFW FraserFC ChoSC BenkePJ ReedSD:Congenital hypothalamic hamartoblastoma hypopituitarism imperforate anus and postaxial polydactyly \u2010 A new syndrome. Part I: Clinical causal and pathogenic considerations. Am J Med Genet p47 1980."},{"key":"e_1_2_1_6_1","first-page":"55","volume-title":"Medical Embryology","author":"Langman J","year":"1978"},{"key":"e_1_2_1_7_1","first-page":"322","volume-title":"Normal and Abnormal Development of the Human Nervous System","author":"Lemire RJ","year":"1975"},{"key":"e_1_2_1_8_1","first-page":"265","article-title":"Hypothalamic tumors in children","volume":"3","author":"Menezes AH","year":"1977","journal-title":"Child's Brain"},{"key":"e_1_2_1_9_1","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1542\/peds.18.6.856","article-title":"Brain tumors in children: Clinical analysis of 164 cases","volume":"18","author":"Odom GL","year":"1956","journal-title":"Pediatrics"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-195110000-00002"},{"key":"e_1_2_1_11_1","first-page":"55","volume-title":"Stedman's Medical Dictionary","year":"1978"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.35.6.776"}],"container-title":["American Journal of Medical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajmg.1320070111","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajmg.1320070111","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,12]],"date-time":"2023-11-12T22:34:24Z","timestamp":1699828464000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajmg.1320070111"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1980,1]]},"references-count":11,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1980,1]]}},"alternative-id":["10.1002\/ajmg.1320070111"],"URL":"https:\/\/doi.org\/10.1002\/ajmg.1320070111","archive":["Portico"],"relation":{},"ISSN":["0148-7299","1096-8628"],"issn-type":[{"value":"0148-7299","type":"print"},{"value":"1096-8628","type":"electronic"}],"subject":[],"published":{"date-parts":[[1980,1]]}}}