{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T17:40:37Z","timestamp":1775929237270,"version":"3.50.1"},"reference-count":13,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,6,2]],"date-time":"2005-06-02T00:00:00Z","timestamp":1117670400000},"content-version":"vor","delay-in-days":8918,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Med. Genet."],"published-print":{"date-parts":[[1981,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Heterogeneity in malignant hyperthermia is being recognized with increasing frequency. In 1973, King described a subgroup of malignant hyperthermia patients with slowly progressive myopathy, short stature, kyphoscoliosis, pectus carinatum, cryptorchidism, and a characteristic facial appearance. Seven cases have been reported, all in males. We present the case of a girl with similar clinical findings who died in a malignant hyperthermia crisis and review the previously reported cases of King syndrome. The delineation of King syndrome provides further evidence for the heterogeneity of malignant hyperthermia and increases awareness of this disorder; its recognition in a female may lead to preoperative diagnosis and prevention of malignant hyperthermia crisis in King syndrome patients.<\/jats:p>","DOI":"10.1002\/ajmg.1320080206","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T17:41:34Z","timestamp":1118511694000},"page":"159-165","source":"Crossref","is-referenced-by-count":32,"title":["The King syndrome: Malignant hyperthermia, myopathy, and multiple anomalies"],"prefix":"10.1002","volume":"8","author":[{"given":"Elspeth W.","family":"McPherson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"Claude A.","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John M.","family":"Opitz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,2]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03005702"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1964.03070250011002"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/34.5.340"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(72)92854-1"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.5848.272"},{"key":"e_1_2_1_7_2","first-page":"640","article-title":"Central core disease associated with elevated creatine phosphokinase levels\u2010two members of a family known to be susceptible to malignant hyperthermia","volume":"48","author":"Isaacs H","year":"1974","journal-title":"S Afr Med J"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1978.00500280007002"},{"key":"e_1_2_1_9_2","first-page":"51A","article-title":"Central core disease and the malignant hyperthermia syndrome","volume":"30","author":"Frank JP","year":"1978","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_10_2","unstructured":"McPhersonE:Malignant hyperthermia: \u201cAn Analysis of the Phenotype and Genetics \u201dmasters thesis. University of Wisconsin 1979 pp36\u201337."},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(73)80309-9"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0028-1091646"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(77)81314-0"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/45.8.901"}],"container-title":["American Journal of Medical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajmg.1320080206","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajmg.1320080206","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,12]],"date-time":"2023-11-12T22:14:02Z","timestamp":1699827242000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajmg.1320080206"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,1]]},"references-count":13,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1981,1]]}},"alternative-id":["10.1002\/ajmg.1320080206"],"URL":"https:\/\/doi.org\/10.1002\/ajmg.1320080206","archive":["Portico"],"relation":{},"ISSN":["0148-7299","1096-8628"],"issn-type":[{"value":"0148-7299","type":"print"},{"value":"1096-8628","type":"electronic"}],"subject":[],"published":{"date-parts":[[1981,1]]}}}