{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T14:09:35Z","timestamp":1756994975349},"reference-count":17,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,6,2]],"date-time":"2005-06-02T00:00:00Z","timestamp":1117670400000},"content-version":"vor","delay-in-days":8918,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Med. Genet."],"published-print":{"date-parts":[[1981,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Familial occurrence of coeliac disease (gluten\u2010sensitive enteropathy, GSE) is well known, but the mode of inheritance remains unclear. Pe\u00f1a et al proposed that the genetic basis for GSE was due to disease\u2010predisposing alleles at two loci: DRw3 at the HLA\u2010D locus and a GSE\u2010associated B\u2010cell alloantigen at another, unlinked locus. They concluded that clinical disease required one DRw3 (dominant inheritance) and two B\u2010cell alloantigen alleles (recessive inheritance), but the observed gene frequencies were not consistent with the observed disease prevalence. Here we examine the gene frequencies allowed, assuming a 2\u2010locus model, under the constraints of known disease prevalence limits and the segregation ratio calculated from 42 published families.<\/jats:p><jats:p>The gene frequencies found by Pe\u00f1a et al predict the segregation ratio observed in the published pedigrees and the best estimates of disease prevalence of GSE, provided (1) a 2\u2010locus model is assumed and (2) both loci exhibit recessive inheritance. The segregation ratio appears incompatible with a 2\u2010locus dominant\u2010recessive model without assuming reduced penetrance.<\/jats:p>","DOI":"10.1002\/ajmg.1320080211","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T17:41:34Z","timestamp":1118511694000},"page":"205-214","source":"Crossref","is-referenced-by-count":25,"title":["Two locus models for gluten sensitive enteropathy: Population genetic considerations"],"prefix":"10.1002","volume":"8","author":[{"given":"David A.","family":"Greenberg","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jerome I.","family":"Rotter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John M.","family":"Opitz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,2]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/S0300-5089(21)00296-0","article-title":"Gluten\u2010sensitive enteropathy","volume":"5","author":"Strober W","year":"1976","journal-title":"Clin Gastroenterol"},{"key":"e_1_2_1_3_2","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/S0300-5089(21)00054-7","article-title":"Genetics of coeliac disease","volume":"2","author":"Stokes PL","year":"1973","journal-title":"Clin Gastroenterol"},{"key":"e_1_2_1_4_2","first-page":"359","article-title":"Family studies in coeliac disease","volume":"43","author":"Mylotte M","year":"1974","journal-title":"Q J Med"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI106958"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(72)91330-X"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(76)90294-4"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365527809181753"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196503042720903"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(19)34444-0"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.12.10.789"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.12.1.79"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.14.5.374"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365527809182200"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(78)90408-0"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-1809.1979.tb00683.x"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-5994.1975.tb04577.x"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(76)93153-6"}],"container-title":["American Journal of Medical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajmg.1320080211","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajmg.1320080211","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,12]],"date-time":"2023-11-12T22:14:22Z","timestamp":1699827262000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajmg.1320080211"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,1]]},"references-count":17,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1981,1]]}},"alternative-id":["10.1002\/ajmg.1320080211"],"URL":"https:\/\/doi.org\/10.1002\/ajmg.1320080211","archive":["Portico"],"relation":{},"ISSN":["0148-7299","1096-8628"],"issn-type":[{"value":"0148-7299","type":"print"},{"value":"1096-8628","type":"electronic"}],"subject":[],"published":{"date-parts":[[1981,1]]}}}