{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T16:05:00Z","timestamp":1792166700239,"version":"4.4.0"},"reference-count":9,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,6,2]],"date-time":"2005-06-02T00:00:00Z","timestamp":1117670400000},"content-version":"vor","delay-in-days":8918,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Med. Genet."],"published-print":{"date-parts":[[1981,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Maroteaux\u2010Lamy syndrome exhibits deficient activity of the enzyme arylsulfatase\u2010B in cultured skin fibroblasts. Prenatal diagnosis was successfully attempted in two pregnancies of a consanguineous Chaldean couple whose first child is affected with Maroteaux\u2010Lamy syndrome. In both instances, deficient arylsulfatase\u2010B activity was observed in amniotic fluid cell cultures, and the diagnosis was confirmed by <jats:sup>35<\/jats:sup>S\u2010sulfate studies and postmortem enzymology and electron microscopy. The prenatal diagnosis of Maroteaux\u2010Lamy syndrome remains problematic. Residual activity of arylsulfatase\u2010B in the affected homozygote can make interpretation difficult, and the behavior of many lysosomal enzymes varies greatly in response to tissue culture conditions and enzyme extraction processes.<\/jats:p>","DOI":"10.1002\/ajmg.1320080215","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T17:41:34Z","timestamp":1118511694000},"page":"235-242","source":"Crossref","is-referenced-by-count":12,"title":["Prenatal diagnosis of Maroteaux\u2010Lamy syndrome"],"prefix":"10.1002","volume":"8","author":[{"given":"Daniel L. 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