{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T14:52:16Z","timestamp":1770216736171,"version":"3.49.0"},"reference-count":44,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,6,2]],"date-time":"2005-06-02T00:00:00Z","timestamp":1117670400000},"content-version":"vor","delay-in-days":8918,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Med. Genet."],"published-print":{"date-parts":[[1981,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The surmised autosomal recessive inheritance of situs inversus of Kartagener syndrome is re\u2010examined on the hypothesis that the homozygous state replaces lateralization of the viscera in normal ontogeny by an indifferent lateralization. The segregation ratio in the progeny of two carrier parents (if there were no ascertainment bias) would then be 1\/8. The estimated segregation ratio under the assumption of complete (truncate) ascertainment is 0.124.<\/jats:p><jats:p>The implications for genetic counseling are discussed.<\/jats:p>","DOI":"10.1002\/ajmg.1320080309","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T18:29:58Z","timestamp":1118514598000},"page":"305-313","source":"Crossref","is-referenced-by-count":24,"title":["Inheritance of Kartagener syndrome"],"prefix":"10.1002","volume":"8","author":[{"given":"Adolfo","family":"Moreno","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edmond A.","family":"Murphy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,2]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.25.6.803"},{"key":"e_1_2_1_3_2","first-page":"139","article-title":"\u00dcber einen Fall von Bronchiectasie bei einem Patient mit Situs inversus Viscerum","volume":"41","author":"Siewert AK","year":"1904","journal-title":"Berl Klin Wochenschr"},{"key":"e_1_2_1_4_2","first-page":"393","article-title":"Bronchiectasis in situs inversus","volume":"3","author":"Oeri R","year":"1901","journal-title":"Frank Zeit Path"},{"key":"e_1_2_1_5_2","first-page":"175","article-title":"Die biologische Bedeutung der Inversionen","volume":"43","author":"G\u00fcnther H","year":"1923","journal-title":"Biol Zentralbl"},{"key":"e_1_2_1_6_2","first-page":"498","article-title":"Zur Pathogenese der Brochiektasien: Bronchiektasien bei Situs Viscerum Inversus","volume":"83","author":"Kartagener M","year":"1933","journal-title":"Beitr Klin Tuberc"},{"key":"e_1_2_1_7_2","first-page":"193","article-title":"Bronchiectasis with situs inversus","volume":"79","author":"Kartagener M","year":"1962","journal-title":"Arch Pediatr"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02091039"},{"key":"e_1_2_1_9_2","first-page":"196","article-title":"A case report of Kartagener's syndrome and statistical observation","volume":"23","author":"Kojima H","year":"1968","journal-title":"Saichin Igakn"},{"key":"e_1_2_1_10_2","first-page":"479","article-title":"The genetics of transposition of the viscera","volume":"7","author":"Cockayne EA","year":"1938","journal-title":"Q J Med"},{"key":"e_1_2_1_11_2","doi-asserted-by":"crossref","unstructured":"TorgersenJ: Familial transposition of viscera with preliminary remarks on genetics and the correlation with diseases of the respiratory tract.Acta Med Scand319\u2013322 1964.","DOI":"10.1111\/j.0954-6820.1946.tb19023.x"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.3109\/00016924709135208"},{"key":"e_1_2_1_13_2","first-page":"361","article-title":"Situs inversus, asymmetry, and twinning","volume":"2","author":"Torgensen J","year":"1950","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_14_2","first-page":"770","article-title":"The triad of Kartagener","volume":"82","author":"Torgensen J","year":"1952","journal-title":"Schweiz Med Wochenschr"},{"key":"e_1_2_1_15_2","first-page":"566","article-title":"Genetic factors in visceral asymmetry and in the development and pathological changes of the lung, heart, and abdominal organs","volume":"47","author":"Torgensen J","year":"1949","journal-title":"Arch Pathol"},{"key":"e_1_2_1_16_2","first-page":"573","article-title":"Situs inversus, bronchiectasis and sinusitis. Report of a family with two cases of Kartagener's triad and two additional cases of bronchiectasis among six siblings","volume":"6","author":"Bergstrom WH","year":"1950","journal-title":"Pediatrics"},{"key":"e_1_2_1_17_2","first-page":"11","article-title":"Kartagener's triad: A family study","volume":"104","author":"Gorham GH","year":"1959","journal-title":"Bull Johns Hopkins Hosp"},{"key":"e_1_2_1_18_2","first-page":"267","article-title":"Dextrocardia with and without transposition of abdominal viscera with report of a case in one monozygotic twin","volume":"18","author":"Lowe CR","year":"1954","journal-title":"Ann Eugen"},{"key":"e_1_2_1_19_2","volume-title":"Principles of Genetic Counseling","author":"Murphy EA","year":"1975"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.127.3298.565"},{"key":"e_1_2_1_20_3","doi-asserted-by":"publisher","DOI":"10.1126\/science.127.3298.569"},{"key":"e_1_2_1_21_2","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1093\/oxfordjournals.jhered.a105760","article-title":"Inherited visceral inversion in mice","volume":"39","author":"Tihen JA","year":"1948","journal-title":"J Hered"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.jhered.a106870"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.jhered.a108749"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-1809.1938.tb02179.x"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-1809.1934.tb02105.x"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-1809.1968.tb00559.x"},{"key":"e_1_2_1_27_2","first-page":"61","article-title":"A simple method of estimating the segregation ratio under complete ascertainment","volume":"20","author":"Li CC","year":"1968","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.1931.0002"},{"key":"e_1_2_1_29_2","first-page":"325","article-title":"Zur Frage der Heredit\u00e4t bei Situs inversus Viscerum totalis","volume":"17","author":"Mattison K","year":"1944","journal-title":"Konstitutionalslehre"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.61.1.56"},{"key":"e_1_2_1_31_2","first-page":"1053","article-title":"Cases of transposition of viscera showing heredity","volume":"83","author":"Randolph BM","year":"1905","journal-title":"NY Med J"},{"key":"e_1_2_1_32_2","first-page":"111","article-title":"Successful treatment with mucolytic agent acetyl cysteine","volume":"90","author":"Imperato PJ","year":"1964","journal-title":"Am Rev Resp Dis"},{"key":"e_1_2_1_33_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.66.2.225"},{"key":"e_1_2_1_34_2","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod12.5.541"},{"key":"e_1_2_1_35_2","doi-asserted-by":"publisher","DOI":"10.1038\/262494a0"},{"key":"e_1_2_1_36_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197707072970101"},{"key":"e_1_2_1_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(78)91511-8"},{"key":"e_1_2_1_38_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197711032971814"},{"key":"e_1_2_1_39_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1084576"},{"key":"e_1_2_1_40_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.149.3682.424"},{"key":"e_1_2_1_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9681(70)90104-9"},{"key":"e_1_2_1_42_2","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/S0096-5588(20)32282-0","article-title":"Situs inversus, sinusitis and bronchiectasis","volume":"7","author":"Adams R","year":"1937","journal-title":"J Thoracic Surg"},{"key":"e_1_2_1_43_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1945.02860130013004"},{"key":"e_1_2_1_44_2","first-page":"1011","article-title":"Dextrocardia with situs inversus. Report of eight cases with a review of the literature on dextrocardia","volume":"46","author":"Caplan SM","year":"1946","journal-title":"Navy Med Bull"}],"container-title":["American Journal of Medical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajmg.1320080309","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajmg.1320080309","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,12]],"date-time":"2023-11-12T22:43:51Z","timestamp":1699829031000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajmg.1320080309"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,1]]},"references-count":44,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1981,1]]}},"alternative-id":["10.1002\/ajmg.1320080309"],"URL":"https:\/\/doi.org\/10.1002\/ajmg.1320080309","archive":["Portico"],"relation":{},"ISSN":["0148-7299","1096-8628"],"issn-type":[{"value":"0148-7299","type":"print"},{"value":"1096-8628","type":"electronic"}],"subject":[],"published":{"date-parts":[[1981,1]]}}}