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In the exploration phase (1956\u20131966), the first family was reanalyzed, other families were ascertained and analysed, and some radiologic aspects of the anomaly were published. The modern phase (1968\u20131972) is characterized by a large series of studies on the clinical aspects of acheiropodia, including laboratory and radiological examinations, psychological tests, status of vision, electrocardiograms, etc. In the contemporary phase (since 1974), genetic aspects prevailed, and studies were published on segregation analysis, selection pressure, genetic load, mutation rate, etc. Each one of these 4 phases is analyzed in detail.<\/jats:p>","DOI":"10.1002\/ajmg.1320090108","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T18:34:18Z","timestamp":1118514858000},"page":"31-41","source":"Crossref","is-referenced-by-count":20,"title":["Historical note: The extraordinary handless and footless families of Brazil \u2013 50 years of acheiropodia"],"prefix":"10.1002","volume":"9","author":[{"given":"Ademar","family":"Freire\u2010Maia","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John M.","family":"Opitz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,2]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.1975.tb00304.x"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320020402"},{"issue":"10","key":"e_1_2_1_4_2","article-title":"International Nomenclature of Constitutional Diseases of Bone with Bibliography","author":"Rimoin DL","year":"1979","journal-title":"Birth Defects"},{"key":"e_1_2_1_5_2","first-page":"46","article-title":"Hereditary absence of hands and feet","volume":"14","author":"Peacock W","year":"1929","journal-title":"Eugenical News"},{"key":"e_1_2_1_6_2","first-page":"59","article-title":"More about the handless and footless family of Brazil","volume":"15","author":"Tucker HC","year":"1930","journal-title":"Eugenical News"},{"key":"e_1_2_1_7_2","first-page":"86","article-title":"The handless and footless family of Brazil again","volume":"15","author":"Cook HH","year":"1930","journal-title":"Eugenical News"},{"key":"e_1_2_1_8_2","first-page":"143","article-title":"Further light on the handless and footless family of Brazil","volume":"15","author":"Bohomoletz M","year":"1930","journal-title":"Eugenical News"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0074-02761947000200009"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(70)92004-0"},{"key":"e_1_2_1_11_2","first-page":"274","volume-title":"Aspectos roentgenol\u00f3gicos da aquiropodia","author":"Koehler RA","year":"1961"},{"key":"e_1_2_1_12_2","first-page":"1","article-title":"Estudos sobre os primeriros aquir\u00f3podos descritos na literatura","volume":"2","author":"Quelce\u2010Salgado A","year":"1966","journal-title":"Estudos, FFCL Mar\u00edlia"},{"key":"e_1_2_1_13_2","unstructured":"RostandJ(1933):Les Probl\u00e8mes de l'h\u00e9r\u00e9dit\u00e9 et du sexe. 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