{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T06:06:10Z","timestamp":1761717970250},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,6,2]],"date-time":"2005-06-02T00:00:00Z","timestamp":1117670400000},"content-version":"vor","delay-in-days":8918,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Med. Genet."],"published-print":{"date-parts":[[1981,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The neural tube defects (anencephaly, encephalocele, spina bifida cystica), oral clefts (cleft lip \u00b1 palate, posterior cleft palate), omphalocele, and diaphragmatic hernia associate with one another far more frequently than at the expected random combination rates. The combination of other abnormalities does not exceed the expected rate. Thus, two or more combinations of schisis\u2010type abnormalities without other defects were treated as a provisional entity. The schisis\u2010association is practically a lethal abnormality. It occurs more often in girls (sex ratio: 0.33), in twins (4.6%), in breech presentations (13.7%), in association with lower mean birth weight (1,931 gm), and in association with a shorter gestation period (36.4 weeks). Mothers of affected children have a significantly higher miscarriage rate; occurrence of schisis\u2010type abnormalities was found in 3.7% of the sibs of index patients. However, except for one, the sib\u2010occurrences of schisis abnormalities were isolated neural tube defects or oral clefts.<\/jats:p>","DOI":"10.1002\/ajmg.1320100105","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T17:38:42Z","timestamp":1118511522000},"page":"25-35","source":"Crossref","is-referenced-by-count":139,"title":["Schisis\u2010association"],"prefix":"10.1002","volume":"10","author":[{"given":"Andrew","family":"Czeizel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John M.","family":"Opitz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,2]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/000992287301201107"},{"key":"e_1_2_1_3_1","first-page":"253","article-title":"The OEIS complex (omphalocele, exstrophy, imperforate anus, spinal defects)","volume":"14","author":"Carey JC","year":"1978","journal-title":"BD: OAS"},{"key":"e_1_2_1_4_1","first-page":"149","article-title":"The baseline data of the Hungarian Congenital Malformation Register, 1970\u20131976","volume":"19","author":"Czeizel A","year":"1978","journal-title":"Acta Paediatr Acad Sci Hung"},{"key":"e_1_2_1_5_1","unstructured":"CzeizelA(1981): Classification and registration of multiple congenital abnormalities.Acta Morphol Acad Sci Hung(in press)."},{"key":"e_1_2_1_6_1","unstructured":"CzeizelA TelegdiL TusnadyG(1981): A multidimensional threshold model of multiple congenital abnormalities.Biometrics(in preparation)."},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.16.2.157"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.169.3952.1329"},{"key":"e_1_2_1_9_1","first-page":"137","volume-title":"Syndromes of the Head and Neck","author":"Gorlin RJ","year":"1976"},{"key":"e_1_2_1_10_1","first-page":"6","article-title":"Anomaliekomplex und Zufallssyndromie","volume":"84","author":"G\u00fcnther H","year":"1948","journal-title":"Zentralbl Allg Pathol, Pathol Anat"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.39.207.519"},{"key":"e_1_2_1_12_1","first-page":"149","volume-title":"Anencephaly","author":"Lemire RJ","year":"1978"},{"key":"e_1_2_1_13_1","first-page":"71","volume-title":"Advances in Human Genetics","author":"Opitz M","year":"1979"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02222706"},{"key":"e_1_2_1_15_1","unstructured":"RochesP:Zur Fage der Anenkephalie; Pr\u00e4paration von 9 F\u00e1llen des Pathologischen Institutes Inaugural Dissertation. Basel: Birkhauser 1951."},{"key":"e_1_2_1_16_1","first-page":"73","article-title":"Anencephaly and unilateral cleft lip and palate in conjoined twins","volume":"5","author":"Rowlatt U","year":"1978","journal-title":"Cleft Palate J"},{"key":"e_1_2_1_17_1","volume-title":"Congenital Malformations","author":"Warkany J","year":"1971"}],"container-title":["American Journal of Medical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajmg.1320100105","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajmg.1320100105","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T03:47:54Z","timestamp":1699847274000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajmg.1320100105"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,1]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1981,1]]}},"alternative-id":["10.1002\/ajmg.1320100105"],"URL":"https:\/\/doi.org\/10.1002\/ajmg.1320100105","archive":["Portico"],"relation":{},"ISSN":["0148-7299","1096-8628"],"issn-type":[{"value":"0148-7299","type":"print"},{"value":"1096-8628","type":"electronic"}],"subject":[],"published":{"date-parts":[[1981,1]]}}}