{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T20:47:49Z","timestamp":1760906869844},"reference-count":21,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,6,2]],"date-time":"2005-06-02T00:00:00Z","timestamp":1117670400000},"content-version":"vor","delay-in-days":8918,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Med. Genet."],"published-print":{"date-parts":[[1981,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A 29\u2010year\u2010old infertile man with mild eunuchoid body proportions and unilateral gynecomastia with a low sperm count had normal chromosomes in lymphocytes and skin fibroblasts. Serum testosterone, urinary ketosteroid, and follicle\u2010stimulating hormone levels were normal, but serum prolactin, luteinizing hormone, and estrogen levels were above normal. Testicular biopsy showed hypocellularity, a pacuity of maturing sperm, and increased lipid content in early spermatogonia. Cytogenetic analysis of the testicular material showed probable 46,XY\/47,XXY mosaicism in spermatogonial cells. None of the cells in diakinesis and metaphase I showed the extra\u2010X as a univalent, and 50% of the cells in diakinesis were hypodiploid with intact XY bivalents. Further analysis of spermatogenesis revealed polymorphic dyads, triads, tetrads, and uncleaved meiotic products of first and second meiosis. Sex chromatin studies of testicular cells showed that 20% of the cells were X\u2010chromatin positive. Scanning electron microscopic study of sperm revealed a wide range of polymorphisms, with some uncleaved meiotic products maturing into double\u2010headed and double\u2010tailed sperm or sperm with bulbous middle pieces or protrusions. A cyto\u2010genetic basis for the origin of these abnormalities is presented.<\/jats:p>","DOI":"10.1002\/ajmg.1320100205","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T17:39:07Z","timestamp":1118511547000},"page":"119-131","source":"Crossref","is-referenced-by-count":5,"title":["A Study of mitosis, meiosis, histology, and scanning electron microscopic details of spermatogenesis in an infertile male with probable 46,XY\/47,XXY germinal mosaicism"],"prefix":"10.1002","volume":"10","author":[{"given":"Barathur R.","family":"Rajendra","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming\u2010liang","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louis","family":"Amorosa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonard J.","family":"Sciorra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John M.","family":"Opitz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,2]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(70)90949-9"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1242\/jcs.11.3.699","article-title":"The organization and polarity of pollen mother cells in Triticum aestivum","volume":"11","author":"Dover GA","year":"1972","journal-title":"J Cell Sci"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1530\/jrf.0.0130315"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1530\/jrf.0.0250401"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.130.5.726"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)39733-3"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-5223.1970.tb02327.x"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(70)90946-3"},{"key":"e_1_2_1_10_1","first-page":"214","article-title":"Meiotic studies in the human male","volume":"1","author":"Kjessler B","year":"1970","journal-title":"Mod Trends Hum Genet"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.1974.tb01673.x"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)43458-8"},{"key":"e_1_2_1_13_1","first-page":"189","volume-title":"La meiose dans les st\u00e9riliti\u00e9s masculines. 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