{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T21:25:36Z","timestamp":1764019536050},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,6,2]],"date-time":"2005-06-02T00:00:00Z","timestamp":1117670400000},"content-version":"vor","delay-in-days":8494,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Med. Genet."],"published-print":{"date-parts":[[1982,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Study of phenotype and familial distribution of malignant hyperthermia (MH) suggests heterogeneity with MH possibly being a symptom of several disorders. Review of all reported family studies supports the concept of heterogeneity with autosomal dominant inheritance in about one\u2010half of the families. There is no strong evidence for other mendelian patterns of inheritance, but sporadic and possibly multifactorially determined cases are common. MH is also seen in other musculoskeletal disorders. We report 12 Wisconsin families with MH and outline a preliminary approach to the counseling of MH patients and their families.<\/jats:p>","DOI":"10.1002\/ajmg.1320110304","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T18:40:04Z","timestamp":1118515204000},"page":"273-285","source":"Crossref","is-referenced-by-count":34,"title":["The genetics of malignant hyperthermia: Evidence for heterogeneity"],"prefix":"10.1002","volume":"11","author":[{"given":"Elspeth","family":"McPherson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"Claude A.","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John M.","family":"Opitz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,2]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03004694"},{"key":"e_1_2_1_3_2","first-page":"84","volume-title":"International Symposium on Malignant Hyperthermia","author":"Brown L","year":"1973"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/45.2.185"},{"key":"e_1_2_1_5_2","first-page":"126","article-title":"Strabismus as a possible sign of latent muscular disease predisposing to suxamethonium induced injury","volume":"2","author":"Tammisto T","year":"1973","journal-title":"Ann Clin Res"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197110072851503"},{"key":"e_1_2_1_7_2","first-page":"9","volume-title":"Malignant Hyperthermia: Curent Concepts","author":"Britt BA","year":"1977"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(73)80309-9"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03005702"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-196904000-00022"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/45.8.901"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.3.5826.559"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(60)92690-8"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03005788"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(72)92854-1"},{"key":"e_1_2_1_16_2","first-page":"16","article-title":"Abnormal serum and muscle creatine phosphokinase (CPK) isoenzyme pattern in a family with malignant hyperthermia","volume":"22","author":"Zsigmond EK","year":"1973","journal-title":"Anaesthetist"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/42.12.1077"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/44.7.742"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1978.00500280007002"},{"key":"e_1_2_1_20_2","first-page":"15A","article-title":"Central core disease and the malignant hyperthermia syndrome","volume":"30","author":"Frank JP","year":"1978","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_21_2","first-page":"1270","article-title":"Succinylcholine and malignant hyperthermia","volume":"31","author":"Kalow W","year":"1972","journal-title":"Fed Proc"},{"key":"e_1_2_1_22_2","first-page":"141","volume-title":"Malignant Hyperthermia \u2013 Current Concepts","author":"Williams CH","year":"1977"},{"key":"e_1_2_1_23_2","first-page":"141","volume-title":"Second International Symposium on Malignant Hyperthermia","author":"Eikelenboom G","year":"1978"},{"key":"e_1_2_1_24_2","first-page":"79","volume-title":"Malignant Hyperthermia \u2013 Current Concepts","author":"Wingard D","year":"1977"}],"container-title":["American Journal of Medical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajmg.1320110304","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajmg.1320110304","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T00:58:46Z","timestamp":1699837126000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajmg.1320110304"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1982,3]]},"references-count":23,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1982,3]]}},"alternative-id":["10.1002\/ajmg.1320110304"],"URL":"https:\/\/doi.org\/10.1002\/ajmg.1320110304","archive":["Portico"],"relation":{},"ISSN":["0148-7299","1096-8628"],"issn-type":[{"value":"0148-7299","type":"print"},{"value":"1096-8628","type":"electronic"}],"subject":[],"published":{"date-parts":[[1982,3]]}}}