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The sequence of replication in the majority of cells is p11, q11, q13, q22\u201324, q12, p22, q26, q28, q27, q25, and p21, q21. Thus p11 is the earliest region to replicate, and q21 is the last. In 66% of 127 cells analyzed, the replication pattern is asymmetric, and bands q12, q26, and q28 are most likely to be out of phase on the two sides of the breakpoint. We find that band p22 has a delay of replication compared to an abnormal X derived from two X chromosomes joined at the q23 region previously reported by us. Structural rearrangement may therefore delay replication in the region of the break.<\/jats:p>","DOI":"10.1002\/ajmg.1320110307","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T18:40:04Z","timestamp":1118515204000},"page":"305-317","source":"Crossref","is-referenced-by-count":5,"title":["DNA replication sequence in a dicentric (functionally monocentric) X chromosome formed by the joining of two X chromosomes at region p22"],"prefix":"10.1002","volume":"11","author":[{"given":"C. W.","family":"Yu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. H.","family":"Priest","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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