{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T09:42:26Z","timestamp":1786700546022,"version":"build-2736575974"},"reference-count":21,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,6,2]],"date-time":"2005-06-02T00:00:00Z","timestamp":1117670400000},"content-version":"vor","delay-in-days":8463,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Med. Genet."],"published-print":{"date-parts":[[1982,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We report studies of six patients with the Angelman \u201cHappy Puppet\u201d sydrome and compare the data with those from previous reports. The results confirm the classic findings of severe mental retardation, \u201cpuppet\u2010like\u201d gait, characteristic craniofacial abnormalities, and frequent episodes of laughter and suggest that this syndrome is more common than previously thought. Computerized axial tomographs of the brain demonstrating unilateral cerebellar atrophy in one patient constitute the first direct evidence of cerebellar abnormalities in this syndrome.<\/jats:p>","DOI":"10.1002\/ajmg.1320110411","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T18:41:34Z","timestamp":1118515294000},"page":"453-460","source":"Crossref","is-referenced-by-count":80,"title":["The Angelman (\u201cHappy Puppet\u201d) syndrome"],"prefix":"10.1002","volume":"11","author":[{"given":"Charles A.","family":"Williams","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaime L.","family":"Frias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John M.","family":"Opitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,6,2]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.1965.tb07844.x"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.42.223.298"},{"key":"e_1_2_1_4_2","first-page":"72","article-title":"Angelman's (\u201cHappy Puppet\u201d) syndrome","volume":"123","author":"Berg JM","year":"1972","journal-title":"Am J Dis Child"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.1973.tb04867.x"},{"key":"e_1_2_1_6_2","first-page":"91","article-title":"\u201cThe Happy Puppet\u201d syndrome","volume":"19","author":"Kibel MA","year":"1973","journal-title":"Cent Afr J Med"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0028-1091738"},{"key":"e_1_2_1_8_2","first-page":"282","article-title":"Ocular manifestations of the happy puppet syndrome","volume":"10","author":"Massey JY","year":"1973","journal-title":"J Pediatr Ophthalmol"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1177\/000992287501401003"},{"key":"e_1_2_1_10_2","first-page":"247","article-title":"Sindrome de Angelman o de la marioneta alegre","volume":"68","author":"Comas AP","year":"1976","journal-title":"Col Assoc Med P Rica"},{"key":"e_1_2_1_11_2","first-page":"183","article-title":"Happy Puppet\u201d syndrome ou syndrome du \u201cpantin hilaire","volume":"31","author":"Pelc S","year":"1976","journal-title":"Helv Paediatr Acta"},{"key":"e_1_2_1_12_2","first-page":"1077","article-title":"Le syndrome de la \u201cmarionette joyeuse\u201d","volume":"105","author":"Halal F","year":"1976","journal-title":"Union Med Can"},{"key":"e_1_2_1_13_2","first-page":"45","article-title":"Happy puppet syndrome","volume":"143","author":"Godfrey M","year":"1976","journal-title":"Nurs Mirror"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00295701"},{"key":"e_1_2_1_15_2","series-title":"BD:OAS","first-page":"635","volume-title":"Dermatoglyphic studies in the \u201cHappy Puppet\u201d syndrome","author":"Podruch PE","year":"1979"},{"key":"e_1_2_1_16_2","first-page":"858","article-title":"The happy puppet syndrome, possible psychological profile","volume":"28","author":"Hersh J","year":"1980","journal-title":"(Abstract) Clin Research"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.7.1.26"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneurpsyc.1939.02270220011001"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.40.8.815"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/73.4.453"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1148\/104.1.1"},{"key":"e_1_2_1_22_2","unstructured":"EnochH WilliamsC KingG FriasJ:Cephalometric analysis in patients with the Angelman syndrome(in preparation)."}],"container-title":["American Journal of Medical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajmg.1320110411","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajmg.1320110411","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T01:04:22Z","timestamp":1699837462000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajmg.1320110411"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1982,4]]},"references-count":21,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1982,4]]}},"alternative-id":["10.1002\/ajmg.1320110411"],"URL":"https:\/\/doi.org\/10.1002\/ajmg.1320110411","archive":["Portico"],"relation":{},"ISSN":["0148-7299","1096-8628"],"issn-type":[{"value":"0148-7299","type":"print"},{"value":"1096-8628","type":"electronic"}],"subject":[],"published":{"date-parts":[[1982,4]]}}}