{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T07:30:19Z","timestamp":1772782219751,"version":"3.50.1"},"reference-count":9,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,6,2]],"date-time":"2005-06-02T00:00:00Z","timestamp":1117670400000},"content-version":"vor","delay-in-days":8463,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Med. Genet."],"published-print":{"date-parts":[[1982,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We evaluated 22 patients with end\u2010stage renal disease (ESRD) due to adult polycystic kidney disease (APKD) to assess their knowledge of the hereditary nature of the condition and to determine whether they received adequate genetic counseling. Patients were evaluated by means of a questionnaire and a review of their medical records. Only 5 of 22 (23%) knew their disorder was hereditary at the time of diagnosis, and in only 4 (18%) was genetic counseling suggested. In no instance had proband and spouse received genetic counseling together. Diagnostic studies of children at risk were rarely suggested.<\/jats:p><jats:p>We also evaluated the children of 9 probands for APKD. Of 26 children evaluated, 17 had APKD (65%). Sixteen had no children at the time of testing. All but two of the 26 were less than 25 years old. Of the probands' children over 15 years of age, 55% knew the name of the condition in the family but only 9% knew they should be tested. Our study demonstrated inadequacy of genetic counseling and follow\u2010up in this group of patients; we suggest that referral for counseling become a routine part of their management. Early diagnosis and effective counseling has the potential benefit for the individuals of making rational reproductive decisions appropriate for their situation. Counseling may have to be repeated during the course of the patients' disease, as their perception of risk may change with time. With advances in dialysis and transplantation, ESRD may not be as devastating in years to come as it is now.<\/jats:p>","DOI":"10.1002\/ajmg.1320110412","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T18:41:34Z","timestamp":1118515294000},"page":"461-468","source":"Crossref","is-referenced-by-count":21,"title":["Genetic counseling in adult polycystic kidney disease"],"prefix":"10.1002","volume":"11","author":[{"given":"Shobha","family":"Sahney","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lester","family":"Weiss","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathan W.","family":"Levin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John M.","family":"Opitz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,2]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"328","article-title":"Bilateral polycystic disease of the kidneys: A follow\u2010up of two hundred eighty\u2010four patients and their families","volume":"38","author":"Dalgaard OZ","year":"1957","journal-title":"Acta Med Scand [Suppl]"},{"key":"e_1_2_1_3_2","first-page":"1223","volume-title":"Diseases of the Kidney","author":"Dalgaard OZ","year":"1963"},{"key":"e_1_2_1_4_2","unstructured":"\u201cThe Kidney: Adult Polycystic Kidney Disease.\u201d Martinez\u2010Maldonado M National Kidney Foundation 1976 vol 9 (1)."},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-194910000-00007"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1955.02960240023006"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1952.01260020331015"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291700030841"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.12.3.217"},{"key":"e_1_2_1_10_2","first-page":"355","article-title":"Does genetic counselling influence risk attitudes and decision making?","volume":"15","author":"Lubs ML","year":"1979","journal-title":"Birth Defects"}],"container-title":["American Journal of Medical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajmg.1320110412","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajmg.1320110412","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T01:04:24Z","timestamp":1699837464000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajmg.1320110412"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1982,4]]},"references-count":9,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1982,4]]}},"alternative-id":["10.1002\/ajmg.1320110412"],"URL":"https:\/\/doi.org\/10.1002\/ajmg.1320110412","archive":["Portico"],"relation":{},"ISSN":["0148-7299","1096-8628"],"issn-type":[{"value":"0148-7299","type":"print"},{"value":"1096-8628","type":"electronic"}],"subject":[],"published":{"date-parts":[[1982,4]]}}}