{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T03:39:34Z","timestamp":1774323574295,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,6,2]],"date-time":"2005-06-02T00:00:00Z","timestamp":1117670400000},"content-version":"vor","delay-in-days":8372,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Med. Genet."],"published-print":{"date-parts":[[1982,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In a study designed to clarify the relationship of HLA\u2010B27 and sacroiliitis, 45 members of seven Old Order Amish families were thoroughly evaluated for sacroiliitis. The primary study group was three sibs who carried HLA\u2010B27 and three of their other sibs who inherited the alternate non\u2010B27 haplotype, their spouses and offspring. The seventh B27 positive family was more distantly related. The study was undertaken with no prior knowledge of disease in these families. These families represented all the B27\u2010positive subjects who had been ascertained up to the time the study began. In these selected families, 24% of the members were found to have sacroiliitis, irrespective of whether they were B27 positive. Analysis of the relevance of HLA to disease in this kindred was confounded by the presence of Bw39 and B17, antigens associated with psoriatic arthritis. However, not all B27\u2010negative cases possessed one or both of these specificities. Rather than clarifying the relationship of B27 to disease, this study, in a highly consanguineous kindred, indicated that other nonlinked loci may be epistatic to B27, that other HLA alleles may be involved, or that certain causes are more prevalent in the Amish than in the non\u2010Amish population.<\/jats:p>","DOI":"10.1002\/ajmg.1320120311","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T18:44:29Z","timestamp":1118515469000},"page":"333-342","source":"Crossref","is-referenced-by-count":5,"title":["Sacroiliitis in the old order Amish"],"prefix":"10.1002","volume":"12","author":[{"given":"Frank C.","family":"Arnett","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roger W.","family":"Enlow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wilma B.","family":"Bias","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John M.","family":"Opitz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,2]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"649","article-title":"HLA\u2010Bw38 and Bw39 in psoriatic arthritis: Relationships and implications for peripheral and axial involvement","volume":"23","author":"Arnett FC","year":"1980","journal-title":"Arthritis Rheum"},{"key":"e_1_2_1_3_1","first-page":"193","article-title":"Cross\u2010reactive HLA antigens in B27\u2010negative Reiter syndrome and sacroiliitis","volume":"141","author":"Arnett FC","year":"1977","journal-title":"Johns Hopkins Med J"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(73)91360-3"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(73)91091-X"},{"issue":"3","key":"e_1_2_1_6_1","first-page":"44","article-title":"HLA B27 and sacroiliitis in Pima Indians\u2013association in males only","volume":"4","author":"Calin A","year":"1977","journal-title":"J Rheumatol"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197510232931701"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1977.03270510035017"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-84-1-1"},{"key":"e_1_2_1_10_1","volume-title":"Descendants of Christian Fisher and other Amish\u2010Mennonite Pioneer Families","author":"Egeland J","year":"1972"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780231205"},{"key":"e_1_2_1_12_1","first-page":"314","volume-title":"Population Studies of Rheumatic Diseases, Proceedings of the III International Symposium","author":"Gofton JP","year":"1966"},{"key":"e_1_2_1_13_1","first-page":"314","article-title":"HL\u2010A 27 and ankylosing spondylitis in B.C. 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