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The spectrum includes deletion of the short arm of chromosome 15, interstitial deletion of 15q1.2, inverted duplication of 15p (tetrasomy 15p), partial trisomy 15 different from that encountered in this patient, and a variety of aberrations involving other chromosomes. A hypothesis that the chromosome aberrations are due to a presumed gene for the PLWS may have merit and could be tested in the laboratory by exposing chromosomes of patients with PLWS to mutagens to search for secondary chromosome derangements.<\/jats:p>","DOI":"10.1002\/ajmg.1320130412","type":"journal-article","created":{"date-parts":[[2005,6,12]],"date-time":"2005-06-12T00:45:33Z","timestamp":1118537133000},"page":"431-438","source":"Crossref","is-referenced-by-count":34,"title":["The cytogenetic controversy in the Prader\u2010Labhart\u2010Willi syndrome"],"prefix":"10.1002","volume":"13","author":[{"given":"Boris G.","family":"Kousseff","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,2]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00278725"},{"key":"e_1_2_1_3_1","first-page":"63","article-title":"The XX male: Report on a child and an 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