{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T10:46:29Z","timestamp":1790419589059,"version":"4.1.0"},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,6,2]],"date-time":"2005-06-02T00:00:00Z","timestamp":1117670400000},"content-version":"vor","delay-in-days":8068,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Med. Genet."],"published-print":{"date-parts":[[1983,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We describe the clinical findings and natural history of an autosomal dominant form of partial lipodystrophy found in four affected individuals from three generations in the same family. The lipodystrophy was present from infancy\/early childhood, involved primarily the face and local areas on the buttocks, and was nonprogressive. Affected individuals also had the Rieger anomaly, midface hypoplasia, short stature, retarded bone age, and hypotrichosis. An affected woman developed insulinopenic diabetes mellitus at 39 yr and another had glucose intolerance at 55 yr.<\/jats:p>","DOI":"10.1002\/ajmg.1320150104","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T15:40:53Z","timestamp":1118504453000},"page":"29-38","source":"Crossref","is-referenced-by-count":53,"title":["Autosomal dominant partial lipodystrophy associated with Rieger anomaly, short stature, and insulinopenic diabetes"],"prefix":"10.1002","volume":"15","author":[{"given":"Dagfinn","family":"Aarskog","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leiv","family":"Ose","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helene","family":"Pande","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nils","family":"Eide","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John M.","family":"Opitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,6,2]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"1","volume-title":"Dysgenesis Mesodermalis of the Iris and the Cornea.\u201d Assen","author":"Alkemade PPH","year":"1969"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01222107"},{"key":"e_1_2_1_4_1","first-page":"33","article-title":"Familial lipoatrophic diabetes with dominant transmission","volume":"43","author":"Dunnigan MG","year":"1974","journal-title":"Q J Med"},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1542\/peds.44.4.564","article-title":"Rieger's syndrome","volume":"44","author":"Feingold M","year":"1969","journal-title":"Pediatrics"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.15.1.30"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197902223000808"},{"key":"e_1_2_1_8_1","first-page":"398","article-title":"Lipoatrophy produced in mice and rabbits by a fraction prepared from the urine from patients with congenital generalized lipodystrophy","volume":"80","author":"Foss I","year":"1975","journal-title":"Acta Endocrinol (Kbh)"},{"key":"e_1_2_1_9_1","volume-title":"Malformation Syndromes","author":"Gorlin R","year":"1975"},{"issue":"2","key":"e_1_2_1_9_2","first-page":"46","author":"National Foundation\u2014March of Dimes","journal-title":"BD:OAS"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(78)80500-9"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320020310"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00430347"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(74)80507-X"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-65213-4_2"},{"key":"e_1_2_1_15_1","first-page":"180","article-title":"The pathogenesis of diabetes mellitus in generalized lipodystrophy","volume":"12","author":"Seip M","year":"1975","journal-title":"Mod Probl Paediatr"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.33.4.593"},{"key":"e_1_2_1_17_1","volume-title":"Malformation Syndromes","author":"Sensenbrenner JA","year":"1975"},{"issue":"2","key":"e_1_2_1_17_2","first-page":"423","author":"National Foundation\u2014March of Dimes","journal-title":"BD:OAS"}],"container-title":["American Journal of Medical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajmg.1320150104","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajmg.1320150104","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T11:09:34Z","timestamp":1697800174000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajmg.1320150104"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983,5]]},"references-count":18,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1983,5]]}},"alternative-id":["10.1002\/ajmg.1320150104"],"URL":"https:\/\/doi.org\/10.1002\/ajmg.1320150104","archive":["Portico"],"relation":{},"ISSN":["0148-7299","1096-8628"],"issn-type":[{"value":"0148-7299","type":"print"},{"value":"1096-8628","type":"electronic"}],"subject":[],"published":{"date-parts":[[1983,5]]}}}