{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,12]],"date-time":"2024-09-12T15:53:46Z","timestamp":1726156426558},"reference-count":16,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,6,2]],"date-time":"2005-06-02T00:00:00Z","timestamp":1117670400000},"content-version":"vor","delay-in-days":7854,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Med. Genet."],"published-print":{"date-parts":[[1983,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We report here retrospective data on 991 liveborn and stillborn infants with neural tube defects (NTDs) born to Utah residents from January 1, 1940 to December 31, 1979. Data were obtained from multiple sources including approximately 1.25 million vital statistics records and several hundred physician and hospital charts. Causal heterogeneity among NTD patients is presumed because 6% of our cases have other congenital anomalies not part of the NTD field defect. A significant association of NTDs with oral clefts is noted. Sex ratios and empiric recurrence risks for isolated NTDs and NTDs associated with other major malformations are also calculated.<\/jats:p>","DOI":"10.1002\/ajmg.1320160410","type":"journal-article","created":{"date-parts":[[2005,6,12]],"date-time":"2005-06-12T00:46:37Z","timestamp":1118537197000},"page":"519-525","source":"Crossref","is-referenced-by-count":33,"title":["Phenotypic heterogeneity in neural tube defects: A clue to causal heterogeneity"],"prefix":"10.1002","volume":"16","author":[{"given":"R. A.","family":"Martin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. M.","family":"Fineman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. B.","family":"Jorde","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John M.","family":"Opitz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,2]]},"reference":[{"key":"e_1_2_1_2_1","volume-title":"Recent Advances and New Syndromes","author":"Bartley JA","year":"1978"},{"issue":"6","key":"e_1_2_1_2_2","first-page":"127","author":"The National Foundation\u2014March of Dimes","journal-title":"BD: OAS"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320100105"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320100105"},{"key":"e_1_2_1_5_1","volume-title":"Epidemiology of Anencephaly and Spina Bifida","author":"Elwood JM","year":"1980"},{"key":"e_1_2_1_6_1","first-page":"155","volume-title":"Syndromes of the Head and Neck","author":"Gorlin RJ","year":"1976"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197602122940704"},{"key":"e_1_2_1_8_1","doi-asserted-by":"crossref","unstructured":"JordeLB FinemanRM MartinRA(1983):Epidemiology of neural tube defects in Utah 1940\u201079. (Submitted for publication).","DOI":"10.1093\/oxfordjournals.aje.a113765"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a113335"},{"issue":"6","key":"e_1_2_1_10_1","first-page":"980","article-title":"Etiologic heterogeneity of neural tube defects. II. Clues from family studies","volume":"34","author":"Khoury MJ","year":"1982","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_11_1","first-page":"49","volume-title":"Anencephaly","author":"Lemire RJ","year":"1978"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.2307\/4594425"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320120408"},{"key":"e_1_2_1_14_1","first-page":"285","volume-title":"Banbury Report 4: Cancer Incidence in Defined Populations","author":"Skolnick MH","year":"1980"},{"key":"e_1_2_1_15_1","first-page":"198","volume-title":"Congenital Malformations","author":"Warkany J","year":"1971"},{"key":"e_1_2_1_16_1","first-page":"209","article-title":"A genetic study of cleft lip and palate in Utah","volume":"15","author":"Woolf CM","year":"1963","journal-title":"Am J Hum Genet"}],"container-title":["American Journal of Medical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajmg.1320160410","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajmg.1320160410","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T13:52:12Z","timestamp":1697723532000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajmg.1320160410"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983,12]]},"references-count":16,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1983,12]]}},"alternative-id":["10.1002\/ajmg.1320160410"],"URL":"https:\/\/doi.org\/10.1002\/ajmg.1320160410","archive":["Portico"],"relation":{},"ISSN":["0148-7299","1096-8628"],"issn-type":[{"value":"0148-7299","type":"print"},{"value":"1096-8628","type":"electronic"}],"subject":[],"published":{"date-parts":[[1983,12]]}}}