{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T20:04:05Z","timestamp":1791317045463,"version":"4.3.1"},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,6,3]],"date-time":"2005-06-03T00:00:00Z","timestamp":1117756800000},"content-version":"vor","delay-in-days":7824,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Med. Genet."],"published-print":{"date-parts":[[1984,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Eleven cytogenetically documented patients with the fragile X syndrome were evaluated for hyperextensibility of the finger joints and the presence of other manifestations of connective tissue dysfunction. All of the patients had hyperextensibility of several finger joints and many had features such as flat feet, highly arched palate and the ability to voluntarily dislocate finger joints. These traits, particularly hyperextensibility of the joints, are a useful aid in the clinical diagnosis of the fragile X syndrome.<\/jats:p>","DOI":"10.1002\/ajmg.1320170106","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T15:00:44Z","timestamp":1118502044000},"page":"111-121","source":"Crossref","is-referenced-by-count":53,"title":["Consideration of connective tissue dysfunction in the fragile X syndrome"],"prefix":"10.1002","volume":"17","author":[{"given":"Randi J.","family":"Hagerman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Van Housen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann C. M.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Loris","family":"McGavran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John M.","family":"Opitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,6,3]]},"reference":[{"key":"e_1_2_1_2_1","unstructured":"Academy of Orthopedic Surgeons(1965). \u201cJoint Motion: Method of Measuring and Recording\u201d. 29 East Madison St Chicago Ill. p83\u201385."},{"key":"e_1_2_1_3_1","first-page":"241","article-title":"Ruptured aortic aneurysm in childhood","volume":"15","author":"Bronson E","year":"1918","journal-title":"Brit J Child Dis"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00447283"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.44.235.387"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320150115"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(81)80660-9"},{"key":"e_1_2_1_8_1","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1542\/peds.69.5.670","article-title":"Treatment of fragile\u2010X","volume":"69","author":"Harpey JP","year":"1982","journal-title":"Pediatr"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320070408"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(82)90991-6"},{"key":"e_1_2_1_11_1","volume-title":"Heritable Disorders of Connective Tissue","author":"McKusick V","year":"1972"},{"key":"e_1_2_1_12_1","unstructured":"OpitzJM(1983). History nosology and bibliography of X\u2010linked mental retardation.Am J Med Genetin press."},{"key":"e_1_2_1_13_1","volume-title":"Personal communication Fragile\u2010X Workshop","author":"Opitz JM","year":"1983"},{"key":"e_1_2_1_14_1","first-page":"231","article-title":"The marker q28 syndrome (\u201cfragile\u2010X syndrome\u201d) in a retarded man with a mitral valve prolapse","volume":"151","author":"Pyeritz RE","year":"1982","journal-title":"Johns Hopkins Med J"},{"key":"e_1_2_1_15_1","volume-title":"Occupational Therapy for Physical Dysfunction","author":"Trombly CA","year":"1977"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(80)80552-X"},{"key":"e_1_2_1_17_1","first-page":"807","article-title":"A marker X chromosome associated with nonspecific male mental retardation","volume":"21","author":"Venter PA","year":"1981","journal-title":"S. Afr Med J"}],"container-title":["American Journal of Medical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajmg.1320170106","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajmg.1320170106","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T15:39:06Z","timestamp":1697729946000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajmg.1320170106"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,1]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1984,1]]}},"alternative-id":["10.1002\/ajmg.1320170106"],"URL":"https:\/\/doi.org\/10.1002\/ajmg.1320170106","archive":["Portico"],"relation":{},"ISSN":["0148-7299","1096-8628"],"issn-type":[{"value":"0148-7299","type":"print"},{"value":"1096-8628","type":"electronic"}],"subject":[],"published":{"date-parts":[[1984,1]]}}}