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The overgrowth of the head was evident in childhood. The characteristic facial appearance was deemed to be present in 60% of the subjects and was recognizable in childhood. Macro\u2010orchidism (MTV of \u2265 30 ml) was present in 80% of the adults but none of the children.<\/jats:p><jats:p>Five subjects had a cleft palate, 11 serious eye disorders (3 with congenital nystagmus), and 4 had torticollis and\/or kyphosis.<\/jats:p><jats:p>Limited information on development suggested that mental retardation was present from early life and was not progressive. Although 3 subjects were autistic (2 with self abuse) most were pleasant, even tempered and cooperative men and boys.<\/jats:p>","DOI":"10.1002\/ajmg.1320170111","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T19:00:44Z","timestamp":1118516444000},"page":"175-194","source":"Crossref","is-referenced-by-count":75,"title":["The fragile X syndrome II: Preliminary data on growth and development in males"],"prefix":"10.1002","volume":"17","author":[{"given":"M. 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