{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T04:50:43Z","timestamp":1761540643854},"reference-count":13,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,6,3]],"date-time":"2005-06-03T00:00:00Z","timestamp":1117756800000},"content-version":"vor","delay-in-days":7733,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Med. Genet."],"published-print":{"date-parts":[[1984,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A couple is presented who underwent prenatal counseling and amniocentesis for sex determination because the wife was an obligate carrier of hemophilia B. Although the fetus was determined to be male, the parents elected not to have further testing to determine if he had hemophilia or not.<\/jats:p><jats:p>The difficulties in the in utero diagnosis of hemophilia B are presented and discussed. In addition, the moral reasoning and decision\u2010making process that this couple went through regarding the decision not to have further fetal testing and to continue the pregnancy is presented and analyzed. These moral decisions appear to be based on family and personal ties, and bonding to the fetus after perception of fetal movement. They combine considerations of the duties and rights involved in such situations, and attend to the anticipated consequences as well.<\/jats:p>","DOI":"10.1002\/ajmg.1320170408","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T19:39:21Z","timestamp":1118518761000},"page":"773-781","source":"Crossref","is-referenced-by-count":1,"title":["Ethical considerations in medical genetics\u2013the prenatal diagnosis of hemophilia B"],"prefix":"10.1002","volume":"17","author":[{"given":"James F.","family":"Smurl","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David D.","family":"Weaver","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Audre","family":"Jarmas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lillie\u2010Mae","family":"Padilla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John M.","family":"Optiz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,3]]},"reference":[{"key":"e_1_2_1_2_1","volume-title":"Principles of Biomedical Ethics","author":"Beauchamp TL","year":"1983"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4684-2010-4_21"},{"key":"e_1_2_1_4_1","volume-title":"Coping with Genetic Disorders","author":"Fletcher JC","year":"1982"},{"key":"e_1_2_1_5_1","volume-title":"In a Different Voice","author":"Gilligan C","year":"1982"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1980.tb07159.x"},{"key":"e_1_2_1_7_1","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1182\/blood.V56.3.397.397","article-title":"Prenatal diagnosis of hemophilia B by an immunoradiometric assay of factor IX","volume":"56","author":"Holmberg L","year":"1980","journal-title":"Blood"},{"key":"e_1_2_1_8_1","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1182\/blood.V50.3.351.351","article-title":"Hemophilia B: Characterization of genetic variants and detection of carriers","volume":"50","author":"Kasper CK","year":"1977","journal-title":"Blood"},{"key":"e_1_2_1_9_1","unstructured":"KohlbergL(1958): \u201cThe Development of Modes of Moral Thinking Choice in the Years Two to Sixteen.\u201d PhD. Dissertation University of Chicago."},{"key":"e_1_2_1_10_1","first-page":"31","volume-title":"Moral Development and Behavior: Research and Social Issues","author":"Kohlberg L","year":"1976"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.4324\/9780203267523"},{"key":"e_1_2_1_12_1","first-page":"485","volume-title":"Fetal\u2010maternal relationship","author":"Mahoney MJ","year":"1978"},{"key":"e_1_2_1_13_1","unstructured":"MibashanRS(1981):Personal communication."},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0049-3848(75)90031-6"}],"container-title":["American Journal of Medical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajmg.1320170408","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajmg.1320170408","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T20:50:28Z","timestamp":1697748628000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajmg.1320170408"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,4]]},"references-count":13,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1984,4]]}},"alternative-id":["10.1002\/ajmg.1320170408"],"URL":"https:\/\/doi.org\/10.1002\/ajmg.1320170408","archive":["Portico"],"relation":{},"ISSN":["0148-7299","1096-8628"],"issn-type":[{"value":"0148-7299","type":"print"},{"value":"1096-8628","type":"electronic"}],"subject":[],"published":{"date-parts":[[1984,4]]}}}