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Taking the pedigree data into account, the conditional probability of homozygosity for the ED gene in that patient was calculated as 97%. Some problems of the clinical and genetic approach to the recognition of the homozygous state in the ED syndrome are discussed using this family as an example.<\/jats:p>","DOI":"10.1002\/ajmg.1320180423","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T19:47:16Z","timestamp":1118519236000},"page":"763-767","source":"Crossref","is-referenced-by-count":2,"title":["Presumed homozygous Ehlers\u2010Danlos syndrome type I in a highly inbred kindred"],"prefix":"10.1002","volume":"18","author":[{"given":"S. I.","family":"Kozlova","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. N.","family":"Prytkov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O. 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