{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T13:27:23Z","timestamp":1780406843625,"version":"3.54.1"},"reference-count":8,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,6,3]],"date-time":"2005-06-03T00:00:00Z","timestamp":1117756800000},"content-version":"vor","delay-in-days":7550,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Med. Genet."],"published-print":{"date-parts":[[1984,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The GAPO syndrome is a rare but distinct autosomal\u2010recessive disorder. The term GAPO is an acronym for the manifestations of Growth retardation, Alopecia, Pseudo\u2010anodontia (failure of tooth eruption), and progressive Optic atrophy. We are aware of five other published patients. All have a strikingly similar appearance. This, along with other distinct manifestations, should allow clear differentiation from other causes of growth retardation. The hypothesis of autosomal\u2010recessive inheritance is based on parental consanguinity and affected sibs in several cases.<\/jats:p>","DOI":"10.1002\/ajmg.1320190202","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T19:53:03Z","timestamp":1118519583000},"page":"209-216","source":"Crossref","is-referenced-by-count":66,"title":["Growth retardation, Alopecia, Pseudo\u2010anodontia, and optic atrophy\u2014The GAPO syndrome: Report of a patient and review of the literature"],"prefix":"10.1002","volume":"19","author":[{"given":"Robert E.","family":"Tipton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J.","family":"Gorlin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,6,3]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"484","article-title":"Et tilfaelde at total \u201cpseudo\u2010anodonti\u201d i forbindelse med kraniedeformitet, dvaergvaekst og ektodermal displasi","volume":"55","author":"Andersen TH","year":"1947","journal-title":"Odont T"},{"key":"e_1_2_1_3_1","first-page":"740","article-title":"Poquiloderma congento familiar (S. de Rothmund\u2010Thomson)","volume":"29","author":"Epps DR","year":"1977","journal-title":"Ciencia Cultura"},{"key":"e_1_2_1_4_1","volume-title":"Ectodermal Dysplasias\u2014A Clinical and Genetic Study","author":"Freire\u2010Maia N","year":"1984"},{"key":"e_1_2_1_5_1","first-page":"155","article-title":"Pseudoanodontia, cranial deformilty blindness, alopecia and dwarfism: A new syndrome","volume":"45","author":"Fuks A","year":"1978","journal-title":"J Dent Child"},{"key":"e_1_2_1_6_1","unstructured":"GorlinRJ TiptonRE LangerLOJr(1978)Pseudoanodontia Growth Retardation and Alopecia: A Syndrome. Paper presented at Annual Meeting of American Academy of Oral Pathology Fort Lauderdale Florida 26 April 1978."},{"key":"e_1_2_1_7_1","first-page":"49","volume-title":"Skeletal Dysplasias","author":"Gorlin RJ","year":"1982"},{"issue":"1","key":"e_1_2_1_8_1","first-page":"14","article-title":"Growth retardation, alopecia, pseudoanodontia and optic atrophy","author":"Shapira Y","year":"1982","journal-title":"Syndrome Identification"},{"key":"e_1_2_1_9_1","first-page":"705","article-title":"Nova sindrome de displasia ectodermica: nanismo, alopecia, anodontia et cutis laxa","volume":"34","author":"Wantjal A","year":"1982","journal-title":"Ciencia Cultura"}],"container-title":["American Journal of Medical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajmg.1320190202","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajmg.1320190202","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T00:59:46Z","timestamp":1697763586000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajmg.1320190202"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,10]]},"references-count":8,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1984,10]]}},"alternative-id":["10.1002\/ajmg.1320190202"],"URL":"https:\/\/doi.org\/10.1002\/ajmg.1320190202","archive":["Portico"],"relation":{},"ISSN":["0148-7299","1096-8628"],"issn-type":[{"value":"0148-7299","type":"print"},{"value":"1096-8628","type":"electronic"}],"subject":[],"published":{"date-parts":[[1984,10]]}}}