{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T14:28:02Z","timestamp":1773066482930,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,6,3]],"date-time":"2005-06-03T00:00:00Z","timestamp":1117756800000},"content-version":"vor","delay-in-days":7519,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Med. Genet."],"published-print":{"date-parts":[[1984,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Controversy over the existence of a fetal hydantoin syndrome continues in medical literature despite numerous recent clinical studies describing additional patients with a characteristic pattern of abnormalities. Resistance to its acceptance as a clinical entity seems to stem from the variability of the component malformations seen in this syndrome. To examine this variability in a controlled experimental situation, we utilized data obtained in previously reported studies of a mouse model of the fetal hydantoin syndrome.<\/jats:p><jats:p>In the mouse, prenatally exposed fetuses had congenital anomalies similar to those observed in the human syndrome. In terms of overall frequency of malformation there were no differences among three inbred mouse strains. However, when considering the individual rates of the 11 most common malformations, considerable differences were noted among the strains. These strain differences in the pattern of malformations appear to be related to genotypic differences in susceptibility to specific malformations. These results provide one possible explanation for the variability observed in the human fetal hydantoin syndrome.<\/jats:p>","DOI":"10.1002\/ajmg.1320190307","type":"journal-article","created":{"date-parts":[[2005,6,12]],"date-time":"2005-06-12T00:47:06Z","timestamp":1118537226000},"page":"463-471","source":"Crossref","is-referenced-by-count":52,"title":["Variable patterns of malformation in the mouse fetal hydantoin syndrome"],"prefix":"10.1002","volume":"19","author":[{"given":"Richard H.","family":"Finnell","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerald F.","family":"Chernoff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,3]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(77)90693-6"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420110105"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420160309"},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1093\/genetics\/84.4.743","article-title":"Genetics of cortisone\u2010induced cleft palate in the mouse: Embryonic and maternal effects","volume":"84","author":"Biddle FG","year":"1976","journal-title":"Genetics"},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1093\/genetics\/85.2.289","article-title":"Cortisone\u2010induced cleft palate in the mouse. A search for the genetic control of the embryonic response trait","volume":"85","author":"Biddle FG","year":"1977","journal-title":"Genetics"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.1978.02120350042006"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420150303"},{"key":"e_1_2_1_9_1","first-page":"59","volume-title":"Phenytoin\u2010Induced Teratology and Gingival Pathology","author":"Finnell RH","year":"1980"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7455686"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1982.tb05429.x"},{"key":"e_1_2_1_12_1","first-page":"171","article-title":"Hydantoin\u2010induced teratogenesis: Are arene oxides intermediates really responsible?","volume":"38","author":"Finnell RH","year":"1983","journal-title":"Helv Paediatr Acta"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(76)80414-3"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1982.tb06091.x"},{"key":"e_1_2_1_15_1","first-page":"211","volume-title":"Epilepsy, Pregnancy and the Child","author":"Janz D","year":"1982"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420160206"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(62)92665-X"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(61)90927-8"},{"key":"e_1_2_1_19_1","first-page":"68","article-title":"Fetales hydantoin\u2010syndrome bei geschwistern","volume":"109","author":"Schinzel A","year":"1979","journal-title":"Schweiz Med Wochenschr"},{"key":"e_1_2_1_20_1","volume-title":"Catalog of Teratogenic Agents","author":"Shepard TH","year":"1976"},{"key":"e_1_2_1_21_1","first-page":"35","volume-title":"Phenytoin\u2010Induced Teratology and Gingival Pathology","author":"Smith DW","year":"1980"},{"key":"e_1_2_1_22_1","first-page":"411","volume-title":"Recognizable Patterns of Human Malformations","author":"Smith DW","year":"1982"},{"key":"e_1_2_1_23_1","volume-title":"Biometry","author":"Sokal RR","year":"1969"},{"key":"e_1_2_1_24_1","first-page":"4333","article-title":"Standardized nomenclature for inbred strains of mice: Sixth listing","volume":"36","author":"Staats J","year":"1976","journal-title":"Cancer Res"}],"container-title":["American Journal of Medical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajmg.1320190307","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajmg.1320190307","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T02:10:00Z","timestamp":1697767800000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajmg.1320190307"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,11]]},"references-count":23,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1984,11]]}},"alternative-id":["10.1002\/ajmg.1320190307"],"URL":"https:\/\/doi.org\/10.1002\/ajmg.1320190307","archive":["Portico"],"relation":{},"ISSN":["0148-7299","1096-8628"],"issn-type":[{"value":"0148-7299","type":"print"},{"value":"1096-8628","type":"electronic"}],"subject":[],"published":{"date-parts":[[1984,11]]}}}