{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T05:23:58Z","timestamp":1697865838165},"reference-count":11,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,6,3]],"date-time":"2005-06-03T00:00:00Z","timestamp":1117756800000},"content-version":"vor","delay-in-days":7519,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Med. Genet."],"published-print":{"date-parts":[[1984,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We surveyed admissions to a pediatric orthopedics hospital for calender years 1957 (polio era) and 1982 (post\u2010polio era). The relative importance of genetic causes of musculoskeletal disease increased after poliomyelitis immunization became universal. Admissions for musculoskeletal disease with a genetic cause (chromosomal, Mendelian, multifactorial, and familial) accounted for 45% of the total in 1957 and 57% in 1982 (p &lt; 0.02); non\u2010genetic causes were 44% in 1957 and 28% in 1982 (p &lt; 0.001). The high probability of recurrent disease in the families of these patients implies that genetics has an important place in the provision of services and in the education of staff in pediatric orthopedic hospitals.<\/jats:p>","DOI":"10.1002\/ajmg.1320190315","type":"journal-article","created":{"date-parts":[[2005,6,12]],"date-time":"2005-06-12T00:47:06Z","timestamp":1118537226000},"page":"533-538","source":"Crossref","is-referenced-by-count":6,"title":["Genetic causes of chronic musculoskeletal disease in childhood are common"],"prefix":"10.1002","volume":"19","author":[{"given":"Diana","family":"Gregory","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paige","family":"Kaplan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles R.","family":"Scriver","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,3]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"1","article-title":"Persistent echoes of the nature\u2010nurture argument","volume":"29","author":"Childs B","year":"1977","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320130315"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-677950-9.50007-6"},{"key":"e_1_2_1_5_1","first-page":"250","article-title":"Phenotypic impact of mendelian disease in man: A measurement (Abstract)","volume":"35","author":"Costa T","year":"1983","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_6_1","first-page":"237","article-title":"The incidence of genetic disease in a university hospital population","volume":"25","author":"Day N","year":"1973","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320010405"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320030407"},{"key":"e_1_2_1_9_1","first-page":"487","article-title":"Window panes of eternity. 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