{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,12]],"date-time":"2025-07-12T22:52:11Z","timestamp":1752360731652},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,6,3]],"date-time":"2005-06-03T00:00:00Z","timestamp":1117756800000},"content-version":"vor","delay-in-days":7519,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Med. Genet."],"published-print":{"date-parts":[[1984,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We present two children\u2014one, 47, XY, + mar, and the other, 47, XY, +21. Both fathers were found to have a 47, XYY chromosome constitution. The initial assumption was that the fathers' aneuploid conditions contributed to those of the offspring. However, the derivation of the marker chromosome could be paternal, maternal, or postzygotic, and examination of polymorphic structures of the number 21 chromosomes of the child with Down syndrome and his parents suggested maternal derivation of the supernumerary 21. To explore further the reproductive risks of an individual with the XYY c\u00f3nstitution, previous reports of reproductive performance and testicular histology are examined as are two theories which suggest XYY males may be at an increased risk of producing aneuploid progeny. Based on these reports, recommendations are made for testing XYY males prior to genetic counseling.<\/jats:p>","DOI":"10.1002\/ajmg.1320190318","type":"journal-article","created":{"date-parts":[[2005,6,12]],"date-time":"2005-06-12T00:47:06Z","timestamp":1118537226000},"page":"553-560","source":"Crossref","is-referenced-by-count":11,"title":["Reproduction in XYY males: Two new cases and implications for genetic counseling"],"prefix":"10.1002","volume":"19","author":[{"given":"F.","family":"Grass","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"McCombs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. I.","family":"Scott","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. S.","family":"Young","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. M.","family":"Moore","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,3]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"15","article-title":"Testicular function of XYY men","volume":"136","author":"Baghdassarian A","year":"1975","journal-title":"Johns Hopkins Med J"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-5223.1971.tb02363.x"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00286847"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-1809.1976.tb00176.x"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00278052"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.68.9.2073"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00293440"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(70)90949-9"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00286865"},{"key":"e_1_2_1_11_1","first-page":"215","article-title":"Small accessory chromosomes (SAC) and their genotype\u2010phenotype correlation","volume":"30","author":"Fryns JP","year":"1982","journal-title":"J Genet Hum"},{"key":"e_1_2_1_12_1","first-page":"165","article-title":"Distributive pairing in man?","volume":"14","author":"Grell RF","year":"1971","journal-title":"Ann Genet"},{"key":"e_1_2_1_13_1","first-page":"22","article-title":"An XYY man with progeny indicating familial tendency to non\u2010disjunction","volume":"14","author":"Hauschka TS","year":"1962","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(70)91245-6"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(70)90946-3"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-1809.1971.tb00239.x"},{"key":"e_1_2_1_17_1","first-page":"76","article-title":"Combination of silver and fluorescent staining for metaphase chromosomes","volume":"30","author":"Lau Y\u2010F","year":"1978","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_18_1","first-page":"7","article-title":"La descendance de sujets 47,XYY. A propos \u010fune famille","volume":"6","author":"Le Marec B","year":"1977","journal-title":"J Gynecol Obstet Biol Reprod"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.1973.tb01169.x"},{"key":"e_1_2_1_20_1","first-page":"796","article-title":"Failure of transmission of the extra chromosome in subjects with 47,XYY karyotype","volume":"2","author":"Melnyk J","year":"1969","journal-title":"Lancet"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197603112941106"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4827(60)90138-5"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00274745"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1159\/000131367"},{"key":"e_1_2_1_25_1","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/S0015-0282(16)39676-5","article-title":"Abnormal spermatogenesis in XYY males: A report on cases ascertained through a population study","volume":"24","author":"Skakkebaek NE","year":"1973","journal-title":"Fertil Steril"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.16.1.66"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(69)90917-9"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(70)92621-8"},{"key":"e_1_2_1_29_1","first-page":"193","article-title":"The D trisomy syndrome and XO gonadal dysgenesis in two sisters","volume":"13","author":"Therman E","year":"1961","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(67)92263-5"},{"key":"e_1_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(66)90113-9"}],"container-title":["American Journal of Medical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajmg.1320190318","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajmg.1320190318","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T02:09:35Z","timestamp":1697767775000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajmg.1320190318"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,11]]},"references-count":30,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1984,11]]}},"alternative-id":["10.1002\/ajmg.1320190318"],"URL":"https:\/\/doi.org\/10.1002\/ajmg.1320190318","archive":["Portico"],"relation":{},"ISSN":["0148-7299","1096-8628"],"issn-type":[{"value":"0148-7299","type":"print"},{"value":"1096-8628","type":"electronic"}],"subject":[],"published":{"date-parts":[[1984,11]]}}}