{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T05:41:13Z","timestamp":1771047673570,"version":"3.50.1"},"reference-count":12,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,6,3]],"date-time":"2005-06-03T00:00:00Z","timestamp":1117756800000},"content-version":"vor","delay-in-days":7489,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Med. Genet."],"published-print":{"date-parts":[[1984,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Although Rh immune globulin is commonly given to Rh\u2010negative women undergoing genetic amniocentesis, there is little documentation of the necessity, efficacy, or safety of this policy. In this study, reproductive outcomes in 147 women each receiving 150 \u03bcg of Rh immune globulin after genetic amniocentesis were compared with those of an equal number of Rh\u2010positive amniocentesis control women. No significant differences were found in the incidence of midtrimester pregnancy loss, mean gestational age at delivery, mean birth weight, or frequency of preterm deliveries (P &gt; 0.05 for all parameters). While two antepartum stillbirths occurred in the study group and none in the control population, causes unrelated to Rh immune globulin administration were apparent for both fetal deaths (one multiple congenital anomaly syndrome, one abruptio placentae at 38 weeks). Of the 103 Rh\u2010negative women giving birth to Rh\u2010positive infants, none were overtly sensitized at the time of delivery. It is concluded that second trimester Rh immune globulin administration does not increase the risk of pregnancy loss.<\/jats:p>","DOI":"10.1002\/ajmg.1320190416","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T13:24:33Z","timestamp":1118496273000},"page":"763-768","source":"Crossref","is-referenced-by-count":5,"title":["Rh immune globulin after genetic amniocentesis: Impact on pregnancy outcome"],"prefix":"10.1002","volume":"19","author":[{"given":"James P.","family":"Crane","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Rohland","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dale","family":"Larson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,3]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"385","article-title":"Suppression of Rh isoimmunization\u2014A review","volume":"52","author":"Bowman JM","year":"1978","journal-title":"Obstet Gynecol"},{"key":"e_1_2_1_3_1","first-page":"625","article-title":"Follow\u2010up of 2,000 second\u2010trimester amniocenteses","volume":"56","author":"Crandall FE","year":"1980","journal-title":"Obstet Gynecol"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.1979.tb04399.x"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970020302"},{"key":"e_1_2_1_6_1","first-page":"389","article-title":"Risks of fetomaternal hemorrhage resulting from amniocentesis with and without ultrasonic placental localization","volume":"46","author":"Harrison R","year":"1975","journal-title":"Obstet Gynecol"},{"key":"e_1_2_1_7_1","first-page":"557","article-title":"Rh immune globulin after amniocentesis for genetic diagnosis","volume":"48","author":"Henry G","year":"1976","journal-title":"Obstet Gynecol"},{"key":"e_1_2_1_8_1","first-page":"459","article-title":"Rh sensitization after genetic amniocentesis","volume":"56","author":"Hill LM","year":"1980","journal-title":"Obstet Gynecol"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320070102"},{"key":"e_1_2_1_10_1","first-page":"48","article-title":"Fetal\u2010maternal bleeding associated with genetic amniocentesis","volume":"55","author":"Mennuti MT","year":"1980","journal-title":"Obstet Gynecol"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(74)90662-0"},{"issue":"2","key":"e_1_2_1_12_1","first-page":"1","article-title":"An assessment of the hazards of amniocentesis","volume":"85","year":"1978","journal-title":"Br J Obstet Gynaecol"},{"key":"e_1_2_1_13_1","first-page":"1245","article-title":"The pathogenesis and prevention of Rh immunization","volume":"97","author":"Zipursky A","year":"1967","journal-title":"Canad Med J"}],"container-title":["American Journal of Medical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajmg.1320190416","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajmg.1320190416","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T00:35:20Z","timestamp":1697762120000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajmg.1320190416"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,12]]},"references-count":12,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1984,12]]}},"alternative-id":["10.1002\/ajmg.1320190416"],"URL":"https:\/\/doi.org\/10.1002\/ajmg.1320190416","archive":["Portico"],"relation":{},"ISSN":["0148-7299","1096-8628"],"issn-type":[{"value":"0148-7299","type":"print"},{"value":"1096-8628","type":"electronic"}],"subject":[],"published":{"date-parts":[[1984,12]]}}}