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Chromosome studies showed two marker chromosomes, the larger of which appeared to be a ring chromosome varying greatly in size, while the smaller one remained constant in size. Chromosome abnormalities may be associated with several forms of hypogonadotropic hypogonadism.<\/jats:p>","DOI":"10.1002\/ajmg.1320200406","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T19:57:59Z","timestamp":1118519879000},"page":"607-612","source":"Crossref","is-referenced-by-count":7,"title":["Multiple congenital anomalies, mental retardation and hypogonadotropic hypogonadism in a boy with small marker chromosomes"],"prefix":"10.1002","volume":"20","author":[{"given":"Kenneth C.","family":"Copeland","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathryn","family":"Hansen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charleen M.","family":"Moore","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John M.","family":"Opitz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James F.","family":"Reynolds","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,3]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"246","article-title":"Familial idiopathic hypogonadotropic hypogonadism","volume":"84","author":"Betend B","year":"1977","journal-title":"Acta Endocrinol"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-43-6-1268"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-1809.1980.tb01556.x"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-1809.1976.tb00176.x"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(72)90019-8"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(75)90924-2"},{"key":"e_1_2_1_8_1","first-page":"203","article-title":"The genetic aspects of primary eunuchoidism","volume":"48","author":"Kallmann FJ","year":"1944","journal-title":"Am J Ment Defic"},{"key":"e_1_2_1_9_1","first-page":"278","article-title":"Chromosome 15 abnormalities and the Prader\u2010Willi syndrome: A follow\u2010up report of 40 cases","volume":"34","author":"Ledbetter DH","year":"1982","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_10_1","first-page":"1051","volume-title":"Mendelian inheritance in Man. Catalogs of Autosomal Dominant, Autosomal Recessive and X\u2010linked Phenotypes","author":"McKusick VA","year":"1983"},{"key":"e_1_2_1_11_1","first-page":"345","article-title":"Syndrome de DeMorsier chez 2 fr\u00e8res dont l'un porteur d'une gonosomic XXY","volume":"36","author":"Sebaoun J","year":"1975","journal-title":"Ann Endocrinol (Paris)"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.13.4.295"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197401032900103"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.13.1.71"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.1975.tb00344.x"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320150307"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.1980.tb01363.x"}],"container-title":["American Journal of Medical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajmg.1320200406","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajmg.1320200406","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T13:52:39Z","timestamp":1697809959000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajmg.1320200406"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,4]]},"references-count":16,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1985,4]]}},"alternative-id":["10.1002\/ajmg.1320200406"],"URL":"https:\/\/doi.org\/10.1002\/ajmg.1320200406","archive":["Portico"],"relation":{},"ISSN":["0148-7299","1096-8628"],"issn-type":[{"value":"0148-7299","type":"print"},{"value":"1096-8628","type":"electronic"}],"subject":[],"published":{"date-parts":[[1985,4]]}}}