{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T12:06:32Z","timestamp":1764936392176},"reference-count":53,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,6,3]],"date-time":"2005-06-03T00:00:00Z","timestamp":1117756800000},"content-version":"vor","delay-in-days":7338,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Med. Genet."],"published-print":{"date-parts":[[1985,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We present case material and a literature survey to document the association between ectopia cordis and band disruption anomalies. The occurrence of thoracic ectopia cordis with a cephalic\u2010pointing cardiac apex suggests an arrest of cardiac descent at 3 weeks of development, consistent with our finding of ectopia cordis in a 28\u2010day human embryo. Mechanical compression secondary to rupture of the chorion and\/or yolk sac at 3 weeks of gestation would interfere with normal cardiac descent and compress the chest, yielding thoracic and pulmonary hypoplasia. Congenital heart defects associated with ectopia cordis may represent deformations secondary to mechanical distortion of the developing heart following early rupture of the chorion and\/or yolk sac. As is illustrated by our clinical specimens, tethering of the heart to periumbilical structures by bands could yield thoracoabdominal ectopia cordis. The milder anomaly of cleft sternum, which is also associated with band disruptions, may occur later in development following rupture of the chorion, yolk sac, or amnion.<\/jats:p>","DOI":"10.1002\/ajmg.1320210128","type":"journal-article","created":{"date-parts":[[2005,6,12]],"date-time":"2005-06-12T00:47:57Z","timestamp":1118537277000},"page":"187-199","source":"Crossref","is-referenced-by-count":86,"title":["Ectopia cordis and cleft sternum: Evidence for mechanical teratogenesis following rupture of the chorion or yolk sac"],"prefix":"10.1002","volume":"21","author":[{"given":"Lawrence C.","family":"Kaplan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rumiko","family":"Matsuoka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enid F.","family":"Gilbert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John M.","family":"Opitz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David M.","family":"Kurnit","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James F.","family":"Reynolds","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,3]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"52","article-title":"Ectopia cordis","volume":"283","author":"Asp K","year":"1961","journal-title":"Acta Chir Scand"},{"key":"e_1_2_1_3_1","first-page":"467","article-title":"Agenesie partielle du sternum","volume":"21","author":"Beaudoing A","year":"1966","journal-title":"Pediatrie"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1016\/S0022-5223(19)42931-0","article-title":"Bifid sternum","volume":"55","author":"Bernhardt L","year":"1968","journal-title":"J Thorac Cardiovasc Surg"},{"key":"e_1_2_1_5_1","first-page":"28A","article-title":"Prenatal detection of amniotic band complex in a twin gestation","volume":"25","author":"Bieber FR","year":"1982","journal-title":"Teratology"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.1942.02010030085005"},{"key":"e_1_2_1_7_1","unstructured":"BrennanPL WeitzmanJJ(1970) \u201cThoracoabdominal ectopia cordis.\u201d Motion picture presented before the American College of Surgeons Oct. 13 1970."},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.4769.1175"},{"key":"e_1_2_1_9_1","first-page":"602","article-title":"A syndrome of congenital defects involving the abdominal wall, sternum, diaphragm, pericardium and heart","volume":"107","author":"Cantrell JR","year":"1958","journal-title":"Surg Gynecol Obstet"},{"key":"e_1_2_1_10_1","first-page":"75","article-title":"Schisisternale completa","volume":"38","author":"Carletti C","year":"1965","journal-title":"Ann Radiol Diagn"},{"key":"e_1_2_1_11_1","first-page":"38","article-title":"An unusual ectopia cordis in a human stillborn infant","volume":"30","author":"Creline ES","year":"1957","journal-title":"Yale J Biol Med"},{"key":"e_1_2_1_12_1","first-page":"333","article-title":"Zur operativen kurrektor des totalen sternumspalte","volume":"12","author":"Daum R","year":"1964","journal-title":"Thoraxchir Vask Chir"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.25.4.490"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-196808000-00017"},{"key":"e_1_2_1_15_1","first-page":"864","article-title":"Ectopia cordis","volume":"28","author":"Friedlieb O","year":"1950","journal-title":"Surgery"},{"key":"e_1_2_1_16_1","first-page":"113","article-title":"Ectopia cordis","volume":"35","author":"Gavrilov LF","year":"1958","journal-title":"Arkh Anat"},{"key":"e_1_2_1_17_1","first-page":"480","article-title":"Cleft sternum and ectopia cordis","volume":"33","author":"Greig DM","year":"1926","journal-title":"Edinburgh Med J"},{"key":"e_1_2_1_18_1","first-page":"15","article-title":"Los defectos del esternon","volume":"8","author":"Gubern\u2010Salissachs L","year":"1972","journal-title":"Rev Esp Pediatr"},{"key":"e_1_2_1_19_1","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1007\/978-1-349-02796-5","volume-title":"Human Embryology","author":"Hamilton WJ","year":"1972"},{"key":"e_1_2_1_20_1","first-page":"157","article-title":"Ein klinischer Beitrag zur Ektopia Cordis","volume":"171","author":"Hienert G","year":"1964","journal-title":"Arch Kinderheilk"},{"key":"e_1_2_1_21_1","first-page":"40","article-title":"Thorakale spaltbildungen Ektopia cordis abdominalis und hernia diaphragmatica sinistra","volume":"76","author":"Hofmann E","year":"1938","journal-title":"Mschr Kinderheilk"},{"key":"e_1_2_1_22_1","first-page":"75","article-title":"Obere sternumspalte","volume":"38","author":"Hofmann S","year":"1965","journal-title":"Dtsch Med Wochenschr"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1959.04320020019004"},{"key":"e_1_2_1_24_1","first-page":"123","article-title":"Observation de bifidite du sternum associee a une angiomatose tracheale","volume":"6","author":"Ingelrans P","year":"1965","journal-title":"Ann Chir Infant"},{"key":"e_1_2_1_25_1","first-page":"932","article-title":"Congenital bifid sternum","volume":"52","author":"Jewett JC","year":"1962","journal-title":"Surgery"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(74)80559-7"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1959.39.1.69"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.17.2.159"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.11.64.205"},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1159\/000144714"},{"key":"e_1_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-197557050-00009"},{"key":"e_1_2_1_32_1","first-page":"181","article-title":"Spaltbildung der vorderen leibswand mit kompletter ektopie des herzens","volume":"6","author":"Lachmann D","year":"1971","journal-title":"Padiatr Padol"},{"key":"e_1_2_1_33_1","first-page":"128","article-title":"Zur operation angeborener sternumspalten","volume":"17","author":"Lambrecht W","year":"1975","journal-title":"Z Kinderhir Grengzeb"},{"key":"e_1_2_1_34_1","first-page":"197","article-title":"Ectopia cordis congenita","volume":"5","author":"Lee ST","year":"1957","journal-title":"Thoraxchir"},{"key":"e_1_2_1_35_1","first-page":"1832","article-title":"Fissura sterni congenita","volume":"48","author":"Meissner F","year":"1964","journal-title":"Z Chir"},{"key":"e_1_2_1_36_1","first-page":"222","article-title":"Uber die Ectopia Cordis","volume":"107","author":"Meitner ER","year":"1959","journal-title":"Anat Anz"},{"key":"e_1_2_1_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(81)80664-6"},{"key":"e_1_2_1_38_1","first-page":"62","volume-title":"The Developing Human: Clinically Oriented Embryology","author":"Moore KL","year":"1974"},{"key":"e_1_2_1_39_1","first-page":"915","article-title":"L'ectocardie thoracique avec fissure sternale","volume":"9","author":"Nguyen\u2010Huu","year":"1952","journal-title":"Arch Fr Pediatr"},{"key":"e_1_2_1_40_1","first-page":"543","article-title":"Un cas d'agenesie sternale operee","volume":"94","author":"Niculescu N","year":"1967","journal-title":"J Chir"},{"key":"e_1_2_1_41_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345660450032301"},{"key":"e_1_2_1_42_1","first-page":"182","article-title":"Ectopia cordis","volume":"26","author":"Prendergast HJ","year":"1943","journal-title":"Minn Med"},{"key":"e_1_2_1_43_1","first-page":"861","article-title":"Un cas d'ectopia cordis avec une etude electrocardiographique de la progression de I'onde d'excitation","volume":"31","author":"Puddu U","year":"1938","journal-title":"Arch Mal Coeur"},{"key":"e_1_2_1_44_1","first-page":"1","volume-title":"Congenital Deformities of the Chest Wall and their Operative Correction","author":"Ravitch MM","year":"1977"},{"key":"e_1_2_1_45_1","first-page":"106","article-title":"Angeborene sternumspalte","volume":"32","author":"Rehbein F","year":"1961","journal-title":"Der Chir"},{"key":"e_1_2_1_46_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-195903000-00016"},{"key":"e_1_2_1_47_1","first-page":"60","article-title":"Morphologie und pathogenese der ectopia cordis congenita","volume":"53","author":"Roth F","year":"1939","journal-title":"Frankfurt Z Pathol"},{"key":"e_1_2_1_48_1","first-page":"12","volume-title":"Recognizable Patterns of Human Deformation","author":"Smith DW","year":"1981"},{"key":"e_1_2_1_49_1","first-page":"488","volume-title":"Recognizable Patterns of Human Malformation","author":"Smith DW","year":"1982"},{"key":"e_1_2_1_50_1","unstructured":"StensenN(1671) \u201cActa Medica et Philosophica Hafniencia Vol. 1.\u201d Quoted In Bartholin T Willis FA (1948)An unusually early description of tetralogy of Fallot. Proc Staff Meeting Mayo Clin23:316."},{"key":"e_1_2_1_51_1","first-page":"778","article-title":"Combined congenital defects of the anterior abdominal wall, sternum, diaphragm, pericardium and heart: A case report and review of the syndrome","volume":"50","author":"Toyama W","year":"1972","journal-title":"Pediatrics"},{"key":"e_1_2_1_52_1","first-page":"422","volume-title":"Heart Disease in Infants, Children, and Adolescents","author":"Van Praagh R","year":"1977"},{"key":"e_1_2_1_53_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.4769.1175"},{"key":"e_1_2_1_54_1","first-page":"878","article-title":"Die sternumspalte","volume":"95","author":"Wischnack H","year":"1970","journal-title":"Z Chir"}],"container-title":["American Journal of Medical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajmg.1320210128","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajmg.1320210128","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T18:03:07Z","timestamp":1697824987000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajmg.1320210128"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,5]]},"references-count":53,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1985,5]]}},"alternative-id":["10.1002\/ajmg.1320210128"],"URL":"https:\/\/doi.org\/10.1002\/ajmg.1320210128","archive":["Portico"],"relation":{},"ISSN":["0148-7299","1096-8628"],"issn-type":[{"value":"0148-7299","type":"print"},{"value":"1096-8628","type":"electronic"}],"subject":[],"published":{"date-parts":[[1985,5]]}}}