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The peculiar cardiac involvement deserves especial attention and raises the question of whether the Watson and LEOPARD syndromes are indistinguishable from NS. Finally, the recent contributions to the variability of the NS phenotype (reports on lymphatic dysplasia, partial deficiency of factor XI, malignant hyperthermia, perceptual\u2010motor disabilities, and endocrine evaluation) are also described.<\/jats:p>","DOI":"10.1002\/ajmg.1320210312","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T19:59:15Z","timestamp":1118519955000},"page":"493-506","source":"Crossref","is-referenced-by-count":365,"title":["Noonan syndrome: A review"],"prefix":"10.1002","volume":"21","author":[{"given":"Heirie M. 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