{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:26:43Z","timestamp":1786976803988,"version":"build-2736575974"},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,6,3]],"date-time":"2005-06-03T00:00:00Z","timestamp":1117756800000},"content-version":"vor","delay-in-days":7215,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Med. Genet."],"published-print":{"date-parts":[[1985,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The Greig cephalopolysyndactyly syndrome in characterized by a set of craniofacial defects (macrocephaly, broad nasal root) leading to peculiar facial appearance, postaxial (occasionally preaxial) polydactyly of hands, preaxial (rarely postaxial) polydactyly of feet, and syndactyly of fingers and toes. Occasionally other skeletal or nonskeletal defects are present. This is an autosomal dominant trait with complete penetrance and variable expressivity. Prognosis for mental and physical development of the affected patients is good, surgery being indicated primarily for aesthetic and functional correction of polydactyly and syndactyly. We report on a Brazilian family in whom the mother and two of three sons were affected.<\/jats:p>","DOI":"10.1002\/ajmg.1320220106","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T15:59:31Z","timestamp":1118505571000},"page":"59-68","source":"Crossref","is-referenced-by-count":34,"title":["The Greig cephalopolysyndactyly syndrome: Report of a family and review of the literature"],"prefix":"10.1002","volume":"22","author":[{"given":"Thomaz Rafael","family":"Gollop","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz Roberto","family":"Fontes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John M.","family":"Opitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James F.","family":"Reynolds","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,6,3]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.1983.tb00080.x"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320130307"},{"key":"e_1_2_1_4_1","first-page":"818","article-title":"Greig cephalopolysyndactyly syndrome","volume":"133","author":"Duncan PA","year":"1979","journal-title":"Am J Dis Child"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00477055"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00441928"},{"key":"e_1_2_1_7_1","first-page":"299","article-title":"Syndrome dominant associant polysyndactylie, pouces en spatule, anomalies faciales et retard mental (une forme particuli\u00e8re de l'acroc\u00e9phalo\u2010polysyndactylie de type Noack)","volume":"19","author":"Gnamey D","year":"1971","journal-title":"J G\u00e9n\u00e9t Hum"},{"key":"e_1_2_1_8_1","first-page":"189","article-title":"Oxycephaly","volume":"33","author":"Greig DM","year":"1926","journal-title":"Edinburgh Med J"},{"key":"e_1_2_1_9_1","first-page":"61","article-title":"Hypertelorismus","volume":"13","author":"G\u00fcnther H","year":"1933","journal-title":"Endokrinologie"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.1972.tb01734.x"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(70)80058-0"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1981.tb05557.x"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320120210"},{"key":"e_1_2_1_14_1","volume-title":"\u201cLimb Malformations,\u201d Part III","author":"Temtamy S","year":"1969"},{"issue":"3","key":"e_1_2_1_14_2","first-page":"125","author":"National Foundation\u2014March of Dimes","journal-title":"BD:OAS"},{"key":"e_1_2_1_15_1","volume-title":"The Genetics of Hand Malformations","author":"Temtamy SA","year":"1978"},{"issue":"3","key":"e_1_2_1_15_2","first-page":"419","author":"National Foundation\u2014March of Dimes","journal-title":"BD:OAS"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320160304"}],"container-title":["American Journal of Medical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajmg.1320220106","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajmg.1320220106","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T14:06:04Z","timestamp":1697810764000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajmg.1320220106"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,9]]},"references-count":17,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1985,9]]}},"alternative-id":["10.1002\/ajmg.1320220106"],"URL":"https:\/\/doi.org\/10.1002\/ajmg.1320220106","archive":["Portico"],"relation":{},"ISSN":["0148-7299","1096-8628"],"issn-type":[{"value":"0148-7299","type":"print"},{"value":"1096-8628","type":"electronic"}],"subject":[],"published":{"date-parts":[[1985,9]]}}}